ID   Y166_STAES              Reviewed;         512 AA.
AC   Q8CU03;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Uncharacterized sensor-like histidine kinase SE_0166;
DE            EC=2.7.13.3;
GN   OrderedLocusNames=SE_0166;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Probable member of the two-component regulatory system
CC       SE_0166/SE_0165. May activate SE_0165 by phosphorylation (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Autophosphorylated. {ECO:0000250}.
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DR   EMBL; AE015929; AAO03763.1; -; Genomic_DNA.
DR   RefSeq; NP_763721.1; NC_004461.1.
DR   RefSeq; WP_002469221.1; NZ_WBME01000072.1.
DR   AlphaFoldDB; Q8CU03; -.
DR   SMR; Q8CU03; -.
DR   STRING; 176280.SE_0166; -.
DR   EnsemblBacteria; AAO03763; AAO03763; SE_0166.
DR   KEGG; sep:SE_0166; -.
DR   PATRIC; fig|176280.10.peg.152; -.
DR   eggNOG; COG2972; Bacteria.
DR   HOGENOM; CLU_525720_0_0_9; -.
DR   OMA; YIWVEHR; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF06580; His_kinase; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Transferase; Transmembrane; Transmembrane helix;
KW   Two-component regulatory system.
FT   CHAIN           1..512
FT                   /note="Uncharacterized sensor-like histidine kinase
FT                   SE_0166"
FT                   /id="PRO_0000299128"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          297..512
FT                   /note="Histidine kinase"
FT   MOD_RES         325
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   512 AA;  60357 MW;  1C50909B5CACB16B CRC64;
     MKTYKPYRHQ LRRSLFASTI FPVFMVMIIG LISFYAIYIW VEHRTIHQHT YQTQTELQRI
     DKHFHTFVTQ QQKQWRHVDL SHPADITKMK RQLLKQVHQQ PAILYYDLKG SSQSFTNNYE
     QLDTTKMYLI SKYRIDFKDD TYILKIYMSS TPLLKNIKKN SGQSALIVDS YDTVLYTNDD
     RFSIGQKYQP PQFGFMNESL KLNSHHAHLI IYKDIHETIE DGIALLVVMG VVLILLVIFG
     YISADRMAKR QSEDIEAIVR KIDDAKNRHL GSYEPLKKHS ELEEINNYIY DLFESNEQLI
     QSIEQTERRL RDIQLKEIER QFQPHFLFNT MQTIQYLIPL SPKVAQTVIQ QLSQMLRYSL
     RTASHTVKLA EELSYIEQYV AIQNIRFDDM IQLYIDATEG VQHQTIGKMM LQPLVENAIK
     HGRDSEPLKI TIRIRLTKRK LHILVHDNGI GMSPSHLEHV RQSLHHDVFD TTHLGLNHLH
     NRAMIQYGTY ARLHIFSRSQ QGTLMCYQIP LV