ID   Y1674_METJA             Reviewed;         634 AA.
AC   Q59068;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=CRISPR-associated protein MJ1674;
GN   OrderedLocusNames=MJ1674;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). The
CC       type III Csm effector complex binds crRNA and acts as a crRNA-guided
CC       RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA
CC       cognate to the crRNA is required for all activities. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Encoded in a type III-A CRISPR locus. {ECO:0000305}.
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DR   EMBL; L77117; AAB99696.1; -; Genomic_DNA.
DR   PIR; H64508; H64508.
DR   RefSeq; WP_010871198.1; NC_000909.1.
DR   AlphaFoldDB; Q59068; -.
DR   SMR; Q59068; -.
DR   STRING; 243232.MJ_1674; -.
DR   EnsemblBacteria; AAB99696; AAB99696; MJ_1674.
DR   GeneID; 1452583; -.
DR   KEGG; mja:MJ_1674; -.
DR   eggNOG; arCOG07641; Archaea.
DR   HOGENOM; CLU_025124_2_0_2; -.
DR   InParanoid; Q59068; -.
DR   OMA; IFEISEW; -.
DR   OrthoDB; 20895at2157; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR013383; CRISPR-assoc_prot_DxTHG_CS.
DR   InterPro; IPR011742; CRISPR-assoc_prot_TM1812.
DR   InterPro; IPR019016; Csx1-like.
DR   Pfam; PF09455; Cas_DxTHG; 1.
DR   TIGRFAMs; TIGR02221; cas_TM1812; 1.
DR   TIGRFAMs; TIGR02549; CRISPR_DxTHG; 1.
PE   4: Predicted;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..634
FT                   /note="CRISPR-associated protein MJ1674"
FT                   /id="PRO_0000107472"
SQ   SEQUENCE   634 AA;  74782 MW;  E91877838C81AB7F CRC64;
     MLKVLISPLG VGDTNTDVYK RQYKTAEYKF EGDIDGIESP FVLSVLIEKL KVDKVIVVGT
     AKSMWEKLYE YYAKEVGEFD EEYWIEIGKK VGMSKYDNYA LSEEDLKKIE KVIDKYLKKI
     NPNAVGGSKC KIIKYGIDKD EIWENFDLFM SLINEVNDGD EIYLDITHSF RSIPLFMYVM
     LEFMRYFKNV KLKGIYYGML DVIRELGHAP VVDLSPIFEI SEWIRGMYEF TTYGNSYLIS
     KLLENEDKEI AEKLQKISRY IDANYLKELR EEVKTLKPLL NEKKDTGRFL KYFIPELHKF
     IDKLKYEDSD FEFQISMAKW NFDNKKYSSG YLCLTDSIFW KLCELYNLPS VYKNREVMKG
     IIYNPSLNKK YSAFGSIKDM HYKRLRNIRN KIAHADVSKK GDDFNPENDL EDVVNLLKNV
     NLPDFDKIIE DLLLDVKNNQ NNKTLKLLKN ILNIQIIRKI IKAYNFESNE IYWDFVSGYL
     LNKNNKCNNE KLREIIEIFH KNIEDAGELE EAFNFVKNTE DEELLDSLAL QNAIMHYALF
     KLSNAYNIKN KEDKEAIKWV LLNQNLCSKH PILKEINNNY HKIFKNKDKP MSNEILEASK
     NIIRLLNSDL SEIKDSVPLN LIIIRYRSYK NNRR