Y1684_ARATH
ID Y1684_ARATH Reviewed; 953 AA.
AC C0LGD7; Q9M9Z0;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g06840;
DE EC=2.7.11.1;
DE Flags: Precursor;
GN OrderedLocusNames=At1g06840; ORFNames=F4H5.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT like protein kinase genes in Arabidopsis thaliana.";
RL BMC Genomics 11:19-19(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- INTERACTION:
CC C0LGD7-2; Q9M9C5: At1g68400; NbExp=2; IntAct=EBI-20651159, EBI-1238661;
CC C0LGD7-2; Q9LFS4: NIK1; NbExp=2; IntAct=EBI-20651159, EBI-16146189;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=C0LGD7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=C0LGD7-2; Sequence=VSP_038290, VSP_038291;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF63151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC011001; AAF63151.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28044.1; -; Genomic_DNA.
DR EMBL; FJ708626; ACN59222.1; -; mRNA.
DR PIR; C86203; C86203.
DR RefSeq; NP_172169.2; NM_100561.4. [C0LGD7-1]
DR AlphaFoldDB; C0LGD7; -.
DR SMR; C0LGD7; -.
DR BioGRID; 22437; 29.
DR IntAct; C0LGD7; 30.
DR STRING; 3702.AT1G06840.1; -.
DR iPTMnet; C0LGD7; -.
DR PaxDb; C0LGD7; -.
DR PRIDE; C0LGD7; -.
DR ProteomicsDB; 228721; -. [C0LGD7-1]
DR EnsemblPlants; AT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
DR GeneID; 837196; -.
DR Gramene; AT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
DR KEGG; ath:AT1G06840; -.
DR Araport; AT1G06840; -.
DR TAIR; locus:2033158; AT1G06840.
DR eggNOG; ENOG502QS0B; Eukaryota.
DR HOGENOM; CLU_000288_14_3_1; -.
DR InParanoid; C0LGD7; -.
DR OMA; HPYTSMD; -.
DR PhylomeDB; C0LGD7; -.
DR PRO; PR:C0LGD7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; C0LGD7; baseline and differential.
DR Genevisible; C0LGD7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Glycoprotein; Kinase;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Receptor;
KW Reference proteome; Repeat; Serine/threonine-protein kinase; Signal;
KW Transferase; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..953
FT /note="Probable LRR receptor-like serine/threonine-protein
FT kinase At1g06840"
FT /id="PRO_0000387540"
FT TOPO_DOM 29..563
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..953
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 85..106
FT /note="LRR 1"
FT REPEAT 107..130
FT /note="LRR 2"
FT REPEAT 132..155
FT /note="LRR 3"
FT REPEAT 156..177
FT /note="LRR 4"
FT REPEAT 180..203
FT /note="LRR 5"
FT REPEAT 204..226
FT /note="LRR 6"
FT REPEAT 228..251
FT /note="LRR 7"
FT REPEAT 253..275
FT /note="LRR 8"
FT REPEAT 276..298
FT /note="LRR 9"
FT REPEAT 299..322
FT /note="LRR 10"
FT REPEAT 323..345
FT /note="LRR 11"
FT REPEAT 352..373
FT /note="LRR 12"
FT REPEAT 374..395
FT /note="LRR 13"
FT DOMAIN 625..897
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 845..868
FT /note="LRR 14"
FT ACT_SITE 749
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 631..639
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 653
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 411
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 502
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 508
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 537
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 695..700
FT /note="MLVYEY -> RADAGL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:20064227"
FT /id="VSP_038290"
FT VAR_SEQ 701..953
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:20064227"
FT /id="VSP_038291"
SQ SEQUENCE 953 AA; 105625 MW; C2EF7F0F4100FDCC CRC64;
MFSTHHVSRL LIPLLFFFLF CCFSSTFAQD DITNPVEVRA LRVIKESLND PVHRLRNWKH
GDPCNSNWTG VVCFNSTLDD GYLHVSELQL FSMNLSGNLS PELGRLSRLT ILSFMWNKIT
GSIPKEIGNI KSLELLLLNG NLLNGNLPEE LGFLPNLDRI QIDENRISGP LPKSFANLNK
TKHFHMNNNS ISGQIPPELG SLPSIVHILL DNNNLSGYLP PELSNMPRLL ILQLDNNHFD
GTTIPQSYGN MSKLLKMSLR NCSLQGPVPD LSSIPNLGYL DLSQNQLNGS IPAGKLSDSI
TTIDLSNNSL TGTIPTNFSG LPRLQKLSLA NNALSGSIPS RIWQERELNS TESIIVDLRN
NGFSNISGRS DLRPNVTVWL QGNPLCSDGN LLRLCGPITE EDINQGSTNS NTTICSDCPP
PYEFSPEPLR RCFCAAPLLV GYRLKSPGFS DFVPYRSEFE QYITSGLSLN LYQLRLDSFQ
WQKGPRLRMY LKFFPVFGSN ANNSFIFNRS EVRRIRGMFT GWNIRDEDLF GPYELMNFTL
LDVYRDVFPS ASPSGLSNGA VAGIVLGSVA AAVTLTAIIA LIIMRKRMRG YSAVARRKRS
SKASLKIEGV KSFTYAELAL ATDNFNSSTQ IGQGGYGKVY KGTLGSGTVV AIKRAQEGSL
QGEKEFLTEI ELLSRLHHRN LVSLLGFCDE EGEQMLVYEY MENGTLRDNI SVKLKEPLDF
AMRLRIALGS AKGILYLHTE ANPPIFHRDI KASNILLDSR FTAKVADFGL SRLAPVPDME
GISPQHVSTV VKGTPGYLDP EYFLTHQLTD KSDVYSLGVV LLELFTGMQP ITHGKNIVRE
INIAYESGSI LSTVDKRMSS VPDECLEKFA TLALRCCREE TDARPSMAEV VRELEIIWEL
MPESHVAKTA DLSETMTHPS SSSNSSIMKH HYTSMDVSGS DLVSGVAPSV APR
