ID   Y1698_STRP1             Reviewed;         280 AA.
AC   Q99YH7; Q48XB6;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DegV domain-containing protein SPy_1698/M5005_Spy1391;
GN   OrderedLocusNames=SPy_1698, M5005_Spy1391;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
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DR   EMBL; AE004092; AAK34450.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ52009.1; -; Genomic_DNA.
DR   RefSeq; NP_269729.1; NC_002737.2.
DR   AlphaFoldDB; Q99YH7; -.
DR   SMR; Q99YH7; -.
DR   STRING; 1314.HKU360_01444; -.
DR   PaxDb; Q99YH7; -.
DR   EnsemblBacteria; AAK34450; AAK34450; SPy_1698.
DR   KEGG; spy:SPy_1698; -.
DR   KEGG; spz:M5005_Spy1391; -.
DR   PATRIC; fig|160490.10.peg.1477; -.
DR   HOGENOM; CLU_048251_2_0_9; -.
DR   OMA; HCENEAD; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   Pfam; PF02645; DegV; 1.
DR   TIGRFAMs; TIGR00762; DegV; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   3: Inferred from homology;
KW   Lipid-binding; Reference proteome.
FT   CHAIN           1..280
FT                   /note="DegV domain-containing protein
FT                   SPy_1698/M5005_Spy1391"
FT                   /id="PRO_0000209808"
FT   DOMAIN          3..280
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         63
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
FT   BINDING         91
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   280 AA;  30874 MW;  1F52E4D9CE84CE12 CRC64;
     MTWKIVTDSG CDLRSLTRQS KELRFERVPL TLQIGTEIFR DDDGLDIDNM MTTMYQSSKA
     TTSSCPSPEA FLQAYRGADN VIVMTITGTL SGSHNSARLA KNELLEENPN VNIHLIDSLS
     AGGEMDLLVL ELERLIKLGL SFEEVVKQIT AYQQKTRLIF VLAKVDNLVK NGRLSKLVGK
     VIGLLNIRMV GKASNKGTLE LLQKARGQKK AVSALIEEIQ KEGYVGGKVY IAHAQNPKIC
     EQISEKIKSL YPDAVIQTGR TSGLCSFYAE DGGLLMGYEI