ID   Y1708_MYCTU             Reviewed;         318 AA.
AC   P9WLT1; L0TA63; O33207; Q7D840;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized protein Rv1708;
GN   OrderedLocusNames=Rv1708;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12657046; DOI=10.1046/j.1365-2958.2003.03425.x;
RA   Sassetti C.M., Boyd D.H., Rubin E.J.;
RT   "Genes required for mycobacterial growth defined by high density
RT   mutagenesis.";
RL   Mol. Microbiol. 48:77-84(2003).
RN   [3]
RP   INDUCTION, AND FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16735741; DOI=10.1099/mic.0.28762-0;
RA   Slayden R.A., Knudson D.L., Belisle J.T.;
RT   "Identification of cell cycle regulators in Mycobacterium tuberculosis by
RT   inhibition of septum formation and global transcriptional analysis.";
RL   Microbiology 152:1789-1797(2006).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: May play a role in septum formation.
CC       {ECO:0000269|PubMed:16735741}.
CC   -!- INDUCTION: Induced by albendazole and thiabendazole, which inhibit the
CC       GTPase activity of FtsZ and probably septum formation.
CC       {ECO:0000269|PubMed:16735741}.
CC   -!- DISRUPTION PHENOTYPE: Essential for growth.
CC       {ECO:0000269|PubMed:12657046}.
CC   -!- SIMILARITY: Belongs to the ParA family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44474.1; -; Genomic_DNA.
DR   PIR; C70504; C70504.
DR   RefSeq; NP_216224.1; NC_000962.3.
DR   RefSeq; WP_003898982.1; NC_000962.3.
DR   AlphaFoldDB; P9WLT1; -.
DR   SMR; P9WLT1; -.
DR   STRING; 83332.Rv1708; -.
DR   PaxDb; P9WLT1; -.
DR   DNASU; 885082; -.
DR   GeneID; 885082; -.
DR   KEGG; mtu:Rv1708; -.
DR   PATRIC; fig|83332.111.peg.1898; -.
DR   TubercuList; Rv1708; -.
DR   eggNOG; COG1192; Bacteria.
DR   OMA; CEFFALR; -.
DR   PhylomeDB; P9WLT1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0043590; C:bacterial nucleoid; IDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025669; AAA_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13614; AAA_31; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..318
FT                   /note="Uncharacterized protein Rv1708"
FT                   /id="PRO_0000390677"
FT   REGION          19..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         72..79
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  34380 MW;  9C44332C997320F3 CRC64;
     MPAGLPGQAS VAVRLSCDVP PDARHHEPRP GMTDHPDTGN GIGLTGRPPR AIPDPAPRSS
     HGPAKVIAMC NQKGGVGKTT STINLGAALG EYGRRVLLVD MDPQGALSAG LGVPHYELDK
     TIHNVLVEPR VSIDDVLIHS RVKNMDLVPS NIDLSAAEIQ LVNEVGREQT LARALYPVLD
     RYDYVLIDCQ PSLGLLTVNG LACTDGVIIP TECEFFSLRG LALLTDTVDK VRDRLNPKLD
     ISGILITRYD PRTVNSREVM ARVVERFGDL VFDTVITRTV RFPETSVAGE PITTWAPKSA
     GALAYRALAR ELIDRFGM