ID   Y1709_STRP8             Reviewed;         280 AA.
AC   Q8NZW1;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DegV domain-containing protein spyM18_1709;
GN   OrderedLocusNames=spyM18_1709;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
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DR   EMBL; AE009949; AAL98241.1; -; Genomic_DNA.
DR   RefSeq; WP_011018090.1; NC_003485.1.
DR   AlphaFoldDB; Q8NZW1; -.
DR   SMR; Q8NZW1; -.
DR   KEGG; spm:spyM18_1709; -.
DR   HOGENOM; CLU_048251_2_0_9; -.
DR   OMA; HCENEAD; -.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   Pfam; PF02645; DegV; 1.
DR   TIGRFAMs; TIGR00762; DegV; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   3: Inferred from homology;
KW   Lipid-binding.
FT   CHAIN           1..280
FT                   /note="DegV domain-containing protein spyM18_1709"
FT                   /id="PRO_0000209811"
FT   DOMAIN          3..280
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         63
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
FT   BINDING         91
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   280 AA;  30876 MW;  BA4F5B44FC47918D CRC64;
     MTWKIVTDSG CDLRSLTRQS KELRFERVPL TLQIGTEIFR DDDGLDIDNM MTTMYQSSKA
     TTSSCPSPEA FLQAYRGSDN VIVMTITGTL SGSHNSARLA KNELLEENPN VNIHLIDSLS
     AGGEMDLLVL ELERLINLGL SFEEVVKQIT AYQQKTRLIF VLAKVDNLVK NGRLSKLVGK
     VIGLLNIRMV GKASNKGTLE LLQKARGQKK AVSALIEEIQ KEGYVGGKVY IAHAQNPKIC
     EQISEKIKSL YPDAVIQTGR TSGLCSFYAE DGGLLMGYEI