ID   Y1711_VIBCH             Reviewed;         789 AA.
AC   Q9KRD1;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=UPF0313 protein VC_1711 {ECO:0000255|HAMAP-Rule:MF_01251};
GN   OrderedLocusNames=VC_1711;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01251};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000255|HAMAP-Rule:MF_01251};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01251}.
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DR   EMBL; AE003852; AAF94861.1; -; Genomic_DNA.
DR   PIR; A82166; A82166.
DR   RefSeq; NP_231347.1; NC_002505.1.
DR   RefSeq; WP_000555510.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KRD1; -.
DR   STRING; 243277.VC_1711; -.
DR   PRIDE; Q9KRD1; -.
DR   DNASU; 2613716; -.
DR   EnsemblBacteria; AAF94861; AAF94861; VC_1711.
DR   KEGG; vch:VC_1711; -.
DR   PATRIC; fig|243277.26.peg.1637; -.
DR   eggNOG; COG1032; Bacteria.
DR   HOGENOM; CLU_018288_2_0_6; -.
DR   OMA; TCMYYTG; -.
DR   BioCyc; VCHO:VC1711-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR020612; Methylthiotransferase_CS.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR024560; UPF0313_C.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF11842; DUF3362; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..789
FT                   /note="UPF0313 protein VC_1711"
FT                   /id="PRO_0000076398"
FT   DOMAIN          363..642
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   REGION          669..789
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..767
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..789
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         377
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         381
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         384
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
SQ   SEQUENCE   789 AA;  88214 MW;  98E3BDE1B83DB53C CRC64;
     MHSEVTPIHH YKKYWAECFG TAPFLPTSRE EMDQLGWDSC DVIIVTGDAY VDHPSFGMAI
     IGRLLEAQGF RVGIIAQPEW QTKDAFMTLG KPNLFFGVTA GNMDSMINRY TADKKIRHDD
     AYTPNNKGGM RPDRCSLVYS QRCREAYKDV PIVLGGIEAS LRRVAHYDYW SDKVRRSILL
     DAKADILLFG NAERALVEVA HRLANGESIN KMVDIRGTAV NLAQVPEHFK IIDSTRIDQP
     NKPFVPSNPY EVETQCATKG DEKEEAQPIT IRPSRHDAKT TAVRLPSFEK LVNDRILYAH
     ASRVLHLETN PYSGRALVQR HGDRELWVNQ APIPLTTEEM DFVFGLYYAR VPHPKYGDAK
     IPAYDMIKTS VNIMRGCFGG CSFCSITEHE GRIIQNRSQE SIINELKEIR DKVPGFTGVI
     SDLGGPTANM YRLGCSDPKA EANCRRPSCV FPGICHKLNT DHKHTIDLYR AARDVDGIKK
     VVIASGVRYD LAIESPEYVR ELVTHHVGGY LKIAPEHTEK GPLSMMMKPG MGTYDRFKEL
     FEKYSAEAGK KQYLIPYFIA AHPGTEDEDM VNLALWLKSN NYRCDQVQNF YPSPMCNATA
     MYHAEVNPLK RVKYKKPEKV PVAKGEAQRR LHKALLRYHD PANWPMIREA LIAMGKRHLI
     GDRPECLIPE KDSDLVTPAQ SRKSGRHGAN RFATKHTHSQ PGFDALRGNK SGGQGRPNSG
     NKSNQGKPAG SKPTGSKPTA NKPAGNQSAR SEQNRGQQGQ RGSATGGKPQ GSGRPASRGN
     TQRQPQRAR