ID   Y1713_FUSNN             Reviewed;         464 AA.
AC   Q8R5Z8;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Uncharacterized RNA methyltransferase FN1713;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=FN1713;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01024}.
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DR   EMBL; AE009951; AAL93828.1; -; Genomic_DNA.
DR   RefSeq; NP_602529.1; NC_003454.1.
DR   AlphaFoldDB; Q8R5Z8; -.
DR   SMR; Q8R5Z8; -.
DR   STRING; 190304.FN1713; -.
DR   EnsemblBacteria; AAL93828; AAL93828; FN1713.
DR   KEGG; fnu:FN1713; -.
DR   PATRIC; fig|190304.8.peg.202; -.
DR   eggNOG; COG2265; Bacteria.
DR   HOGENOM; CLU_014689_7_1_0; -.
DR   InParanoid; Q8R5Z8; -.
DR   OMA; SIIHVMN; -.
DR   BioCyc; FNUC190304:G1FZS-214-MON; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0070041; F:rRNA (uridine-C5-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0070475; P:rRNA base methylation; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR030390; MeTrfase_TrmA_AS.
DR   InterPro; IPR030391; MeTrfase_TrmA_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   PANTHER; PTHR11061; PTHR11061; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01230; TRMA_1; 1.
DR   PROSITE; PS01231; TRMA_2; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..464
FT                   /note="Uncharacterized RNA methyltransferase FN1713"
FT                   /id="PRO_0000161980"
FT   DOMAIN          13..71
FT                   /note="TRAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00208"
FT   ACT_SITE        420
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         295
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         324
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         345
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         393
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
SQ   SEQUENCE   464 AA;  53230 MW;  F8B7A5F51C5F00ED CRC64;
     MMRSSTLKLR NKMLKVSDII QIKIDKIVFG GEGLGYYNGF AVFVPMSIPE DELEIEIISI
     KKTYARGLIK NIIKASPERI DNHKFTFEDF YGCDFAMLKY ESQLKYKRFM VEEVIRKIAG
     LSDIEISDVL ASEDIYNYRN KIIEPFSVYA NKIITGFFKR KSHEVFEVDE NILNSKLGNK
     IIKELKEILN KNKISVYDEN THKGILRNIM IRTNSNNEAM VVLIINSNKI TENIKKLLFK
     LRENIEEIKS IYISLNSKKT NTVIGEKNIL IYGEKSIKEN INRIEFHISP TSFFQINVKQ
     AKRLYDIAIS FFDNIDNKYI VDAYSGTGTI GMIIAKKAKK VYAIEIVKSA SEDGEKTAKE
     NGIENIEFIN GAVEKELVKL VNNNQKIDTI IFDPPRKGLE TSIIDKVAEL NLKEVVYISC
     NPSTFARDVK LFSEKGYVLK KLQAVDMFPQ TSHIECVGLI ERKI