ID   Y1714_MYCTU             Reviewed;         270 AA.
AC   P9WGQ3; L0T923; O53927; Q7D837;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Uncharacterized oxidoreductase Rv1714;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv1714;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44480.1; -; Genomic_DNA.
DR   PIR; B70817; B70817.
DR   RefSeq; NP_216230.1; NC_000962.3.
DR   RefSeq; WP_003408444.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WGQ3; -.
DR   SMR; P9WGQ3; -.
DR   STRING; 83332.Rv1714; -.
DR   PaxDb; P9WGQ3; -.
DR   GeneID; 885159; -.
DR   KEGG; mtu:Rv1714; -.
DR   TubercuList; Rv1714; -.
DR   eggNOG; COG1028; Bacteria.
DR   OMA; REKNSPG; -.
DR   PhylomeDB; P9WGQ3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..270
FT                   /note="Uncharacterized oxidoreductase Rv1714"
FT                   /id="PRO_0000415508"
FT   ACT_SITE        171
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         30..55
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         157
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   270 AA;  27986 MW;  33BAA2B0E04EA3AB CRC64;
     MEEMALAQQV PNLGLARFSV QDKSILITGA TGSLGRVAAR ALADAGARLT LAGGNSAGLA
     ELVNGAGIDD AAVVTCRPDS LADAQQMVEA ALGRYGRLDG VLVASGSNHV APITEMAVED
     FDAVMDANVR GAWLVCRAAG RVLLEQGQGG SVVLVSSVRG GLGNAAGYSA YCPSKAGTDL
     LAKTLAAEWG GHGIRVNALA PTVFRSAVTE WMFTDDPKGR ATREAMLARI PLRRFAEPED
     FVGALIYLLS DASSFYTGQV MYLDGGYTAC