Y1727_PSEAE
ID Y1727_PSEAE Reviewed; 685 AA.
AC Q9I310;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Uncharacterized signaling protein PA1727;
GN OrderedLocusNames=PA1727;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00244}.
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DR EMBL; AE004091; AAG05116.1; -; Genomic_DNA.
DR PIR; H83428; H83428.
DR RefSeq; NP_250418.1; NC_002516.2.
DR RefSeq; WP_003113558.1; NZ_QZGE01000003.1.
DR PDB; 5M1T; X-ray; 2.27 A; A/B=426-685.
DR PDBsum; 5M1T; -.
DR AlphaFoldDB; Q9I310; -.
DR SMR; Q9I310; -.
DR STRING; 287.DR97_160; -.
DR PaxDb; Q9I310; -.
DR EnsemblBacteria; AAG05116; AAG05116; PA1727.
DR GeneID; 881914; -.
DR KEGG; pae:PA1727; -.
DR PATRIC; fig|208964.12.peg.1789; -.
DR PseudoCAP; PA1727; -.
DR HOGENOM; CLU_000445_70_49_6; -.
DR InParanoid; Q9I310; -.
DR OMA; CRQMRQW; -.
DR PhylomeDB; Q9I310; -.
DR BioCyc; PAER208964:G1FZ6-1758-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071111; F:cyclic-guanylate-specific phosphodiesterase activity; IDA:PseudoCAP.
DR GO; GO:0052621; F:diguanylate cyclase activity; IDA:PseudoCAP.
DR GO; GO:0071732; P:cellular response to nitric oxide; IMP:PseudoCAP.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.20.20.450; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR005330; MHYT_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF03707; MHYT; 3.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; SSF141868; 1.
DR SUPFAM; SSF55073; SSF55073; 1.
DR TIGRFAMs; TIGR00254; GGDEF; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50924; MHYT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..685
FT /note="Uncharacterized signaling protein PA1727"
FT /id="PRO_0000170474"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT DOMAIN 6..199
FT /note="MHYT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT DOMAIN 293..425
FT /note="GGDEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00095"
FT DOMAIN 434..685
FT /note="EAL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00074"
FT HELIX 436..442
FT /evidence="ECO:0007829|PDB:5M1T"
FT TURN 443..448
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 450..459
FT /evidence="ECO:0007829|PDB:5M1T"
FT TURN 460..462
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 465..476
FT /evidence="ECO:0007829|PDB:5M1T"
FT TURN 477..479
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 480..482
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 484..486
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 488..494
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 497..517
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 524..528
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 531..535
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 539..549
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 554..556
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 557..562
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 563..568
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 570..582
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 586..592
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 599..604
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 609..612
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 614..618
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 620..622
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 624..640
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 643..647
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 652..661
FT /evidence="ECO:0007829|PDB:5M1T"
FT STRAND 664..668
FT /evidence="ECO:0007829|PDB:5M1T"
FT TURN 669..671
FT /evidence="ECO:0007829|PDB:5M1T"
FT HELIX 677..680
FT /evidence="ECO:0007829|PDB:5M1T"
SQ SEQUENCE 685 AA; 74379 MW; 4BF74F5CF49A40C7 CRC64;
MLISSYNQVL VAFSLIVAIL ASYTALDMAG RVTLAKGREA LSWLIGGAFA MGFGIWSMHF
VGMLAFSLPI PLGYDLGLTL LSLLLAVGSS AFALWLVCQA ELPWQRLALG ALLMGSGIAA
MHYTGMAALL MMPGIVYDPL WLGLSILIAV IASGAALWIA FRLRHGSRRI VLVRAGAALV
MGCAIVGMHY TGMAAAQFPL GSFCGAAGRG IDNGWLAVLV IVITLAVIAI ALIVSVLDSR
LEARTSVLAT SLARANRELI QLALHDNLTK LPNRMLLDDR LEQAIQQAIR DDRRFAVLFM
DLDGFKAVND AYGHHLGDLL LIEVAERIRA NVRAQDTIAR LGGDEFVLLI EAREPADAAT
LAEKLVKRIS QPYQISRHEV RISASIGIAL YPGDGQTRHE LMINADAAMY HAKDQGRNGY
CFFESSMNAN AQEQLQLLHD LRQALERRQL VLHYQPKVLA PNGPMIGVEA LLRWEHPQHG
LITPGQFLPL AEKTGLIVQI GEWVLDEACR QMRLWLDGGH ADWNIAVNLS ALQFAHAGLV
DSVRNALLRH SLEPSHLILE VTESTAMRDA DASLVILEQL SAMGVGISID DFGTGYSSLL
YLKRLPASEL KIDRGFINEL AHDSDDAAIV SAIVALGRTL NLKIVAEGVE TEAQQEFLTR
LGCNSLQGFL LGRPMPAEQL LASVA
