ID   Y1733_MYCTO             Reviewed;         210 AA.
AC   P9WLS8; L0TA85; P71991; Q8VJY0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Probable membrane protein MT1774;
GN   OrderedLocusNames=MT1774;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46047.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46047.1; ALT_INIT; Genomic_DNA.
DR   PIR; H70687; H70687.
DR   RefSeq; WP_003898990.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLS8; -.
DR   EnsemblBacteria; AAK46047; AAK46047; MT1774.
DR   KEGG; mtc:MT1774; -.
DR   PATRIC; fig|83331.31.peg.1903; -.
DR   HOGENOM; CLU_084215_0_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039708; MT1774/Rv1733c-like.
DR   PANTHER; PTHR42305; PTHR42305; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..210
FT                   /note="Probable membrane protein MT1774"
FT                   /id="PRO_0000427426"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  22457 MW;  B59E7B8EAEB3D624 CRC64;
     MIATTRDREG ATMITFRLRL PCRTILRVFS RNSLVRGTDR LEAVVMLLAV TVSLLTIPFA
     AAAGTAVHDS RSHVYAHQAQ TRHPATATVI DHEGVIDSNT TATSAPPRTK ITVPARWVVN
     GIERSGEVNA KPGTKSGDRV GIWVDSAGQL VDEPAPPARA IADAALAALG LWLSVAAVAG
     ALLALTRAIL IRVRNASWQH DIDSLFCTQR