Y1733_MYCTU
ID Y1733_MYCTU Reviewed; 210 AA.
AC P9WLS9; L0TA85; P71991; Q8VJY0;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Probable membrane protein Rv1733c;
GN OrderedLocusNames=Rv1733c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION BY HYPOXIA.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=11416222; DOI=10.1073/pnas.121172498;
RA Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA Schoolnik G.K.;
RT "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT encoding alpha -crystallin.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN [3]
RP INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=12953092; DOI=10.1084/jem.20030205;
RA Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA Sherman D.R., Schoolnik G.K.;
RT "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT tuberculosis dormancy program.";
RL J. Exp. Med. 198:705-713(2003).
RN [4]
RP BIOTECHNOLOGY.
RX PubMed=16931093; DOI=10.1016/j.micinf.2006.03.018;
RA Leyten E.M., Lin M.Y., Franken K.L., Friggen A.H., Prins C.,
RA van Meijgaarden K.E., Voskuil M.I., Weldingh K., Andersen P.,
RA Schoolnik G.K., Arend S.M., Ottenhoff T.H., Klein M.R.;
RT "Human T-cell responses to 25 novel antigens encoded by genes of the
RT dormancy regulon of Mycobacterium tuberculosis.";
RL Microbes Infect. 8:2052-2060(2006).
RN [5]
RP INDUCTION BY CARBON MONOXIDE (CO).
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
RA Shiloh M.U., Manzanillo P., Cox J.S.;
RT "Mycobacterium tuberculosis senses host-derived carbon monoxide during
RT macrophage infection.";
RL Cell Host Microbe 3:323-330(2008).
RN [6]
RP INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA Agarwal A., Steyn A.J.;
RT "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT tuberculosis dormancy regulon.";
RL J. Biol. Chem. 283:18032-18039(2008).
RN [7]
RP BIOTECHNOLOGY.
RX PubMed=19553548; DOI=10.1128/cvi.00111-09;
RA Black G.F., Thiel B.A., Ota M.O., Parida S.K., Adegbola R., Boom W.H.,
RA Dockrell H.M., Franken K.L., Friggen A.H., Hill P.C., Klein M.R.,
RA Lalor M.K., Mayanja H., Schoolnik G., Stanley K., Weldingh K.,
RA Kaufmann S.H., Walzl G., Ottenhoff T.H.;
RT "Immunogenicity of novel DosR regulon-encoded candidate antigens of
RT Mycobacterium tuberculosis in three high-burden populations in Africa.";
RL Clin. Vaccine Immunol. 16:1203-1212(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC carbon monoxide (CO). It is hoped that this regulon will give insight
CC into the latent, or dormant phase of infection.
CC {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092,
CC ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359}.
CC -!- BIOTECHNOLOGY: Has strong T-cell and IFN-gamma inducing capacity in
CC human tuberculin skin test positive patients, indicating this might be
CC a good vaccine candidate. Has also been seen to serve as an immunogenic
CC antigen, inducing gamma-interferon responses in whole-blood cultures
CC from M.tuberculosis-exposed adults in Uganda, The Gambia and South
CC Africa, also indicating this might be a good vaccine candidate.
CC {ECO:0000269|PubMed:16931093, ECO:0000269|PubMed:19553548}.
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DR EMBL; AL123456; CCP44499.1; -; Genomic_DNA.
DR PIR; H70687; H70687.
DR RefSeq; NP_216249.1; NC_000962.3.
DR RefSeq; WP_003911592.1; NZ_NVQJ01000010.1.
DR AlphaFoldDB; P9WLS9; -.
DR STRING; 83332.Rv1733c; -.
DR PaxDb; P9WLS9; -.
DR DNASU; 885214; -.
DR GeneID; 885214; -.
DR KEGG; mtu:Rv1733c; -.
DR TubercuList; Rv1733c; -.
DR eggNOG; ENOG5032YM7; Bacteria.
DR OMA; VWLWRWR; -.
DR PhylomeDB; P9WLS9; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR039708; MT1774/Rv1733c-like.
DR PANTHER; PTHR42305; PTHR42305; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..210
FT /note="Probable membrane protein Rv1733c"
FT /id="PRO_0000392906"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 210 AA; 22458 MW; 5D28C0E240FA9F3C CRC64;
MIATTRDREG ATMITFRLRL PCRTILRVFS RNPLVRGTDR LEAVVMLLAV TVSLLTIPFA
AAAGTAVQDS RSHVYAHQAQ TRHPATATVI DHEGVIDSNT TATSAPPRTK ITVPARWVVN
GIERSGEVNA KPGTKSGDRV GIWVDSAGQL VDEPAPPARA IADAALAALG LWLSVAAVAG
ALLALTRAIL IRVRNASWQH DIDSLFCTQR
