ID   Y1735_MYCTO             Reviewed;         197 AA.
AC   P9WLS4; L0T7I8; P71993; Q7D822;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Uncharacterized membrane protein MT1776;
GN   OrderedLocusNames=MT1776;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
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DR   EMBL; AE000516; AAK46049.1; -; Genomic_DNA.
DR   PIR; B70688; B70688.
DR   RefSeq; WP_003898991.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLS4; -.
DR   EnsemblBacteria; AAK46049; AAK46049; MT1776.
DR   KEGG; mtc:MT1776; -.
DR   HOGENOM; CLU_1609026_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.10.150; -; 1.
DR   InterPro; IPR004695; SLAC1/Mae1/Ssu1/TehA.
DR   InterPro; IPR038665; Voltage-dep_anion_channel_sf.
DR   Pfam; PF03595; SLAC1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..197
FT                   /note="Uncharacterized membrane protein MT1776"
FT                   /id="PRO_0000427428"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   197 AA;  21357 MW;  6093E11868A3B492 CRC64;
     MFLYVAVGSL VVARLLLYPL RPADLTPPYW VAMGATAITV LAGAHIVEMA DAPMAIVTSG
     LVAGASVVFW AFGPWLIPPL VAASIWKHVV HRVPLRYEAT LWSVVFPLGM YGVGAYRLGL
     AAHLPIVESI GEFEGWVALA VWTITFVAML HHLAATIGRS GRSSHAIGAA DDTHAIICRP
     PRSFDHQVRA FRRNQPM