ID   Y1735_MYCTU             Reviewed;         197 AA.
AC   P9WLS5; L0T7I8; P71993; Q7D822;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Uncharacterized membrane protein Rv1735c;
GN   OrderedLocusNames=Rv1735c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
RN   [3]
RP   INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA   Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA   Agarwal A., Steyn A.J.;
RT   "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT   tuberculosis dormancy regulon.";
RL   J. Biol. Chem. 283:18032-18039(2008).
RN   [4]
RP   BIOTECHNOLOGY.
RX   PubMed=19553548; DOI=10.1128/cvi.00111-09;
RA   Black G.F., Thiel B.A., Ota M.O., Parida S.K., Adegbola R., Boom W.H.,
RA   Dockrell H.M., Franken K.L., Friggen A.H., Hill P.C., Klein M.R.,
RA   Lalor M.K., Mayanja H., Schoolnik G., Stanley K., Weldingh K.,
RA   Kaufmann S.H., Walzl G., Ottenhoff T.H.;
RT   "Immunogenicity of novel DosR regulon-encoded candidate antigens of
RT   Mycobacterium tuberculosis in three high-burden populations in Africa.";
RL   Clin. Vaccine Immunol. 16:1203-1212(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC       carbon monoxide (CO). It is hoped that this regulon will give insight
CC       into the latent, or dormant phase of infection.
CC       {ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:18400743}.
CC   -!- BIOTECHNOLOGY: This protein serves as an immunogenic antigen, inducing
CC       gamma-interferon responses in whole-blood cultures from M.tuberculosis-
CC       exposed adults in Uganda, The Gambia and South Africa, indicating this
CC       might be a good vaccine candidate. {ECO:0000269|PubMed:19553548}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP44501.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP44501.1; ALT_INIT; Genomic_DNA.
DR   PIR; B70688; B70688.
DR   RefSeq; NP_216251.1; NC_000962.3.
DR   RefSeq; WP_003898991.1; NC_018143.2.
DR   AlphaFoldDB; P9WLS5; -.
DR   STRING; 83332.Rv1735c; -.
DR   PaxDb; P9WLS5; -.
DR   GeneID; 885216; -.
DR   KEGG; mtu:Rv1735c; -.
DR   PATRIC; fig|83332.12.peg.1930; -.
DR   TubercuList; Rv1735c; -.
DR   eggNOG; COG1275; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.10.150; -; 1.
DR   InterPro; IPR004695; SLAC1/Mae1/Ssu1/TehA.
DR   InterPro; IPR038665; Voltage-dep_anion_channel_sf.
DR   Pfam; PF03595; SLAC1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..197
FT                   /note="Uncharacterized membrane protein Rv1735c"
FT                   /id="PRO_0000392908"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   197 AA;  21357 MW;  6093E11868A3B492 CRC64;
     MFLYVAVGSL VVARLLLYPL RPADLTPPYW VAMGATAITV LAGAHIVEMA DAPMAIVTSG
     LVAGASVVFW AFGPWLIPPL VAASIWKHVV HRVPLRYEAT LWSVVFPLGM YGVGAYRLGL
     AAHLPIVESI GEFEGWVALA VWTITFVAML HHLAATIGRS GRSSHAIGAA DDTHAIICRP
     PRSFDHQVRA FRRNQPM