ID   CAPSD_TASV2             Reviewed;         724 AA.
AC   Q9Q3G5; J9PBU5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-JUN-2021, entry version 59.
DE   RecName: Full=Capsid polyprotein VP90;
GN   ORFNames=ORF2;
OS   Turkey astrovirus 2 (TAstV-2).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC   Stellavirales; Astroviridae; Avastrovirus.
OX   NCBI_TaxID=246343;
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10846102; DOI=10.1128/jvi.74.13.6173-6177.2000;
RA   Koci M.D., Seal B.S., Schultz-Cherry S.;
RT   "Molecular characterization of an avian astrovirus.";
RL   J. Virol. 74:6173-6177(2000).
CC   -!- FUNCTION: Capsid polyprotein VP90: self-assembles to form an
CC       icosahedral T=3 capsid. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- PTM: Specific enzymatic cleavages in vivo yield mature protein(s). VP90
CC       undergoes a cascade of proteolytic cleavages presumably mediated by
CC       host caspases and extracellular proteases (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the astroviridae capsid polyprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AF206663; AAF18464.1; -; Genomic_RNA.
DR   RefSeq; NP_987088.1; NC_005790.1.
DR   PDB; 3TS3; X-ray; 1.49 A; A/B/C/D=423-630.
DR   PDBsum; 3TS3; -.
DR   SMR; Q9Q3G5; -.
DR   GeneID; 2943320; -.
DR   KEGG; vg:2943320; -.
DR   EvolutionaryTrace; Q9Q3G5; -.
DR   Proteomes; UP000007235; Genome.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0039573; P:suppression by virus of host complement activation; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR004337; Capsid_astroviral.
DR   InterPro; IPR029053; Viral_coat.
DR   InterPro; IPR032268; VP90_C.
DR   Pfam; PF03115; Astro_capsid_N; 1.
DR   Pfam; PF16580; Astro_capsid_p2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host-virus interaction;
KW   Inhibition of host complement factors by virus;
KW   T=1 icosahedral capsid protein; Viral immunoevasion; Virion.
FT   CHAIN           1..724
FT                   /note="Capsid polyprotein VP90"
FT                   /id="PRO_0000320243"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          700..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..39
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           428..430
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          437..441
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          455..459
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   HELIX           466..468
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          469..476
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          478..481
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          489..492
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          496..503
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   TURN            505..507
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          509..512
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   HELIX           514..516
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          520..523
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   HELIX           524..527
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   TURN            528..532
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          539..542
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   HELIX           544..546
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   HELIX           551..557
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          564..570
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          575..581
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   TURN            582..585
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          586..595
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   STRAND          609..611
FT                   /evidence="ECO:0007829|PDB:3TS3"
FT   HELIX           618..624
FT                   /evidence="ECO:0007829|PDB:3TS3"
SQ   SEQUENCE   724 AA;  80266 MW;  DB183AC7885EDEF4 CRC64;
     MAAMADKVVV KKTTTRRRGR SNSRSRSRSR SRSRTKKTVK IIEKKPEKSI LKKIDQAERR
     DAKQLRRIRK KVQGPPVNSR MTTVVTLGQI TGNKDNTLER KHKCFLNPLL MKSQETGQTA
     TPLSVRASQY NLWKLSRLHV RLIPLAGKAN ILGSVVFLDL EQEANTAGPE SVDTIKARPH
     VEVPIGSKTV WKVHPRSALG PRQGWWNVDP GDSPTDSLGP ALNMWTYLQT VNALQSAGGT
     QTPYTSALFL VEVLVTYEFS NYGPKPALSQ MVSDSFPPAS GSTATLKNTS DGAVAIQLSG
     AIARKMEEVE PKGRRSNAQT SGVGEVFWAV STEVVNTVAD AIPGWGWLLK GGWFVLRKIF
     GAANDQNGTY LIYSSVADAQ GDNRIYTSVK QTQLTSSRIN LVQLTQPNVN QAAVGGSVGA
     ANSIYLPLPQ ADDQYTPYFV YNFQGERVST TETGVFCLAA IPAATTSSRY NNQITTPSIG
     YRNASGTGTS FLLDAASWWN ILDVTQTGVL FGQPRLGVGV MQTMKTLKQH IKDYTEPAIQ
     KYYPGTTNLD EQLKQRLNLA EGDPVISMGD TNGRRAALFY RTSDEKYILF FSTTEDPGAQ
     YQNLKMLYFW NWSYSDTKQQ FLDHLRTVQF ANLDDSQPAP YDSDDDDLSD VTSLFEQADL
     GDETDFKFNM SIQTSKHLEE EKNYWKNQCE RMMMEKALSG TSQPLVRFEK AGPRADQSSA
     SGHS