ID   Y1739_MYCTA             Reviewed;         312 AA.
AC   A5U388;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MRA_1739;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MRA_1739;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000611; ABQ73488.1; -; Genomic_DNA.
DR   RefSeq; WP_003408497.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U388; -.
DR   SMR; A5U388; -.
DR   STRING; 419947.MRA_1739; -.
DR   EnsemblBacteria; ABQ73488; ABQ73488; MRA_1739.
DR   KEGG; mra:MRA_1739; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; NPFRDHG; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..312
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MRA_1739"
FT                   /id="PRO_0000361224"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..160
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   312 AA;  33654 MW;  D0FA7184385E7FDE CRC64;
     MARTDDDNWD LTSSVGVTAT IVAVGRALAT KDPRGLINDP FAEPLVRAVG LDLFTKMMDG
     ELDMSTIADV SPAVAQAMVY GNAVRTKYFD DYLLNATAGG IRQVAILASG LDSRAYRLPW
     PTRTVVYEID QPKVMEFKTT TLADLGAEPS AIRRAVPIDL RADWPTALQA AGFDSAAPTA
     WLAEGLLIYL KPQTQDRLFD NITALSAPGS MVATEFVTGI ADFSAERART ISNPFRCHGV
     DVDLASLVYT GPRNHVLDYL AAKGWQPEGV SLAELFRRSG LDVRAADDDT IFISGCLTDH
     SSISPPTAAG WR