ID   Y1739_MYCTO             Reviewed;         560 AA.
AC   P9WGF6; L0T947; P71997; Q7D819;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Probable sulfate transporter MT1781;
GN   OrderedLocusNames=MT1781;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46054.1; -; Genomic_DNA.
DR   PIR; F70688; F70688.
DR   RefSeq; WP_003898994.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGF6; -.
DR   BMRB; P9WGF6; -.
DR   SMR; P9WGF6; -.
DR   EnsemblBacteria; AAK46054; AAK46054; MT1781.
DR   KEGG; mtc:MT1781; -.
DR   PATRIC; fig|83331.31.peg.1911; -.
DR   HOGENOM; CLU_003182_13_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   PANTHER; PTHR11814; PTHR11814; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00815; sulP; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sulfate transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..560
FT                   /note="Probable sulfate transporter MT1781"
FT                   /id="PRO_0000428370"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          442..557
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
SQ   SEQUENCE   560 AA;  59324 MW;  A4776A5BF6A5A089 CRC64;
     MIPTMTSAGW APGVVQFREY QRRWLRGDVL AGLTVAAYLI PQAMAYATVA GLPPAAGLWA
     SIAPLAIYAL LGSSRQLSIG PESATALMTA AVLAPMAAGD LRRYAVLAAT LGLLVGLICL
     LAGTARLGFL ASLLSRPVLV GYMAGIALVM ISSQLGTITG TSVEGNEFFS EVHSFATSVT
     RVHWPTFVLA MSVLALLTML TRWAPRAPGP IIAVLAATML VAVMSLDAKG IAIVGRIPSG
     LPTPGVPPVS VEDLRALIIP AAGIAIVTFT DGVLTARAFA ARRGQEVNAN AELRAVGACN
     IAAGLTHGFP VSSSSSRTAL ADVVGGRTQL YSLIALGLVV IVMVFASGLL AMFPIAALGA
     LVVYAALRLI DLSEFRRLAR FRRSELMLAL ATTAAVLGLG VFYGVLAAVA LSILELLRRV
     AHPHDSVLGF VPGIAGMHDI DDYPQAKRVP GLVVYRYDAP LCFANAEDFR RRALTVVDQD
     PGQVEWFVLN AESNVEVDLT ALDALDQLRT ELLRRGIVFA MARVKQDLRE SLRAASLLDK
     IGEDHIFMTL PTAVQAFRRR