Y1739_MYCTU
ID Y1739_MYCTU Reviewed; 560 AA.
AC P9WGF7; L0T947; P71997; Q7D819;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Probable sulfate transporter Rv1739c;
GN OrderedLocusNames=Rv1739c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION BY HYPOXIA.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=11416222; DOI=10.1073/pnas.121172498;
RA Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA Schoolnik G.K.;
RT "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT encoding alpha -crystallin.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN [3]
RP FUNCTION IN E.COLI.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=18255326; DOI=10.1016/j.cbpa.2007.12.005;
RA Zolotarev A.S., Unnikrishnan M., Shmukler B.E., Clark J.S., Vandorpe D.H.,
RA Grigorieff N., Rubin E.J., Alper S.L.;
RT "Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP
RT protein Rv1739c from Mycobacterium tuberculosis.";
RL Comp. Biochem. Physiol. 149:255-266(2008).
RN [4]
RP STRUCTURE BY NMR OF 437-560.
RX PubMed=19636956; DOI=10.1007/s12104-009-9150-z;
RA Sharma A.K., Ye L., Zolotarev A.S., Alper S.L., Rigby A.C.;
RT "NMR assignment and secondary structure of the STAS domain of Rv1739c, a
RT putative sulfate transporter of Mycobacterium tuberculosis.";
RL Biomol. NMR. Assign. 3:99-102(2009).
CC -!- FUNCTION: Expression in E.coli induces sulfate uptake during early- to
CC mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific,
CC requires E.coli CysA and the transmembrane segment but not the STAS
CC domain of the protein. {ECO:0000269|PubMed:18255326}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: A possible member of the dormancy regulon. Induced in
CC response to reduced oxygen tension (hypoxia). It is hoped that this
CC regulon will give insight into the latent, or dormant phase of
CC infection. {ECO:0000269|PubMed:11416222}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP44505.1; -; Genomic_DNA.
DR PIR; F70688; F70688.
DR RefSeq; NP_216255.1; NC_000962.3.
DR RefSeq; WP_003916850.1; NZ_NVQJ01000010.1.
DR AlphaFoldDB; P9WGF7; -.
DR BMRB; P9WGF7; -.
DR SMR; P9WGF7; -.
DR STRING; 83332.Rv1739c; -.
DR PaxDb; P9WGF7; -.
DR DNASU; 887208; -.
DR GeneID; 887208; -.
DR KEGG; mtu:Rv1739c; -.
DR TubercuList; Rv1739c; -.
DR eggNOG; COG0659; Bacteria.
DR OMA; EAPHDIK; -.
DR PhylomeDB; P9WGF7; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0019001; F:guanyl nucleotide binding; IDA:MTBBASE.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0000103; P:sulfate assimilation; IMP:MTBBASE.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50801; STAS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sulfate transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..560
FT /note="Probable sulfate transporter Rv1739c"
FT /id="PRO_0000393282"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 442..557
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..436
FT /note="Required for sulfate transport in E.coli"
SQ SEQUENCE 560 AA; 59367 MW; C184DAEFA4777A85 CRC64;
MIPTMTSAGW APGVVQFREY QRRWLRGDVL AGLTVAAYLI PQAMAYATVA GLPPAAGLWA
SIAPLAIYAL LGSSRQLSIG PESATALMTA AVLAPMAAGD LRRYAVLAAT LGLLVGLICL
LAGTARLGFL ASLRSRPVLV GYMAGIALVM ISSQLGTITG TSVEGNEFFS EVHSFATSVT
RVHWPTFVLA MSVLALLTML TRWAPRAPGP IIAVLAATML VAVMSLDAKG IAIVGRIPSG
LPTPGVPPVS VEDLRALIIP AAGIAIVTFT DGVLTARAFA ARRGQEVNAN AELRAVGACN
IAAGLTHGFP VSSSSSRTAL ADVVGGRTQL YSLIALGLVV IVMVFASGLL AMFPIAALGA
LVVYAALRLI DLSEFRRLAR FRRSELMLAL ATTAAVLGLG VFYGVLAAVA LSILELLRRV
AHPHDSVLGF VPGIAGMHDI DDYPQAKRVP GLVVYRYDAP LCFANAEDFR RRALTVVDQD
PGQVEWFVLN AESNVEVDLT ALDALDQLRT ELLRRGIVFA MARVKQDLRE SLRAASLLDK
IGEDHIFMTL PTAVQAFRRR
