ID   Y1742_SACEN             Reviewed;         287 AA.
AC   A4FAI5;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase SACE_1742;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=SACE_1742;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AM420293; CAM01060.1; -; Genomic_DNA.
DR   RefSeq; WP_009943791.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; A4FAI5; -.
DR   SMR; A4FAI5; -.
DR   STRING; 405948.SACE_1742; -.
DR   DNASU; 4941604; -.
DR   EnsemblBacteria; CAM01060; CAM01060; SACE_1742.
DR   KEGG; sen:SACE_1742; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; CPWLFGT; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..287
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase SACE_1742"
FT                   /id="PRO_0000361263"
FT   BINDING         119
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         148..149
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   287 AA;  31196 MW;  147DD46A471DE550 CRC64;
     MSANEQWDIV SGVGITALAV AVARARESRR DDRLIDDPYA EPLIRAAQPP VPMSGDGGEA
     GALWHEMTDY VSVRSRFFDE WFARACAAGT RQAVVLASGL DTRAFRLEWP EGFRVFEIDQ
     PKVLEFKDGT LAAEGVRASC ERHAVAVDLR DDWASALVKA GFDPALPTAW LAEGLLPYLP
     PEAEANLLAT VHDLSARGSR IAIESIALAR SALLGADLDD TAREWGIDLK GLFSLEDRPD
     PGDVLAQRGW RVHRDPVGDL AAGFRRPLSD RAQQLGAAGE MVTAQRD