ID   Y1744_MYCMM             Reviewed;         281 AA.
AC   B2HIJ9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Uncharacterized oxidoreductase MMAR_1744;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MMAR_1744;
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=216594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M;
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA   Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA   Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA   Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum on the
RT   evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; CP000854; ACC40193.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2HIJ9; -.
DR   SMR; B2HIJ9; -.
DR   STRING; 216594.MMAR_1744; -.
DR   EnsemblBacteria; ACC40193; ACC40193; MMAR_1744.
DR   KEGG; mmi:MMAR_1744; -.
DR   eggNOG; COG0656; Bacteria.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   OMA; KLWPTDQ; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..281
FT                   /note="Uncharacterized oxidoreductase MMAR_1744"
FT                   /id="PRO_0000380737"
FT   ACT_SITE        56
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         114
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         194..246
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   281 AA;  29760 MW;  DF00A3229D6CA4B6 CRC64;
     MPGAPSPSAP SIALNDENTM PVLGMGVAGL SDDETERAVS AALEIGCRLI DTAAAYGNEA
     AVGRAIAASG IPRAELFVTT KVATADHGFT ASREACKASL DRLGLDYVDL YLIHWPAPAA
     GKYVDAFGGL IQARGEGFTR SIGVSNFTEE HVSNVIDLTF VTPAVNQVEL HPLLNQDELR
     KANAQHNVVT QSYTPLALGQ LADNPTVTSI AGEYGKTPTQ VLLRWNLQLG NAVIFGSSNA
     EHIATNLDVF EFELASQHMD AINGLNDGTR LREDPMTFAG V