Y1750_DROME
ID Y1750_DROME Reviewed; 410 AA.
AC Q8INZ1;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Uncharacterized protein CG31750;
GN ORFNames=CG31750;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAN10983.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP DOUBTS ABOUT THE ORIGINAL FUNCTION.
RX PubMed=14608037; DOI=10.1073/pnas.2335847100;
RA Robertson H.M., Warr C.G., Carlson J.R.;
RT "Molecular evolution of the insect chemoreceptor gene superfamily in
RT Drosophila melanogaster.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:14537-14542(2003).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be a putative gustatory receptor
CC named Gr36d but further analysis suggested that this is not the case.
CC {ECO:0000305|PubMed:14608037}.
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DR EMBL; AE014134; AAN10983.1; -; Genomic_DNA.
DR RefSeq; NP_724041.1; NM_165208.1.
DR AlphaFoldDB; Q8INZ1; -.
DR STRING; 7227.FBpp0080518; -.
DR GlyGen; Q8INZ1; 1 site.
DR PaxDb; Q8INZ1; -.
DR EnsemblMetazoa; FBtr0080965; FBpp0080518; FBgn0046888.
DR GeneID; 170887; -.
DR KEGG; dme:Dmel_CG31750; -.
DR UCSC; CG31750-RA; d. melanogaster.
DR FlyBase; FBgn0046888; CG31750.
DR VEuPathDB; VectorBase:FBgn0046888; -.
DR eggNOG; ENOG502T7XN; Eukaryota.
DR GeneTree; ENSGT00540000073694; -.
DR HOGENOM; CLU_056070_0_0_1; -.
DR InParanoid; Q8INZ1; -.
DR OMA; NGHQAIM; -.
DR OrthoDB; 1252074at2759; -.
DR PhylomeDB; Q8INZ1; -.
DR BioGRID-ORCS; 170887; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 170887; -.
DR PRO; PR:Q8INZ1; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0046888; Expressed in gonad and 1 other tissue.
DR Genevisible; Q8INZ1; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 4: Predicted;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..410
FT /note="Uncharacterized protein CG31750"
FT /id="PRO_0000216508"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..72
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 150..170
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..189
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 190..210
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 250..270
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..293
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 294..314
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..378
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 379..399
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..410
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT CARBOHYD 272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 410 AA; 48502 MW; 920996292C8077F5 CRC64;
MPEKKGHEIP LRNSRKKWLS HLLRWSVSSI CWISYIIYRG VVVGQMKFDP RNRKMIIHPR
NIWTKRISLL LKILAMLWDY YFIQYLCSAI LPIFSNKSER FFNNLIEAIA VQLSLWNTAR
LYSWLNSLSW NRSFVDRVND VIRLNGHLKS ILGPLSLDSI SLLILYVVHL QFTVLQTINH
PYMIPMVNTL LLGLICNVYV AYQMLLLSWI AAINNFLKYS QPEQQPNRKQ RKNLLRLLRI
YAKISNVHQD IKVLWLPVAS MLFSNIVELV RNWSYIIEWI FFHRRKTVMQ KWSFIFWKYL
GGGLAPLLRM LLIGLCNDRL VQMQDFLNLQ LLIIDLRHTK FKQLDGNFVS QFKSLQTCFD
LQLRAQPIRN QIMSLNQECG CPFALDFFFC TVLNSISCVQ YKMANEINND
