Y175_HELPY
ID Y175_HELPY Reviewed; 299 AA.
AC P56112;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Putative peptidyl-prolyl cis-trans isomerase HP_0175;
DE Short=PPIase HP_0175;
DE EC=5.2.1.8;
DE AltName: Full=Rotamase HP_0175;
DE Flags: Precursor;
GN OrderedLocusNames=HP_0175;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
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DR EMBL; AE000511; AAD07245.1; -; Genomic_DNA.
DR PIR; G64541; G64541.
DR RefSeq; NP_206974.1; NC_000915.1.
DR RefSeq; WP_000739470.1; NC_018939.1.
DR PDB; 5EZ1; X-ray; 2.40 A; A/B=33-299.
DR PDB; 6BHF; X-ray; 2.09 A; A=1-299.
DR PDBsum; 5EZ1; -.
DR PDBsum; 6BHF; -.
DR AlphaFoldDB; P56112; -.
DR SMR; P56112; -.
DR DIP; DIP-3058N; -.
DR IntAct; P56112; 2.
DR MINT; P56112; -.
DR STRING; 85962.C694_00870; -.
DR PaxDb; P56112; -.
DR EnsemblBacteria; AAD07245; AAD07245; HP_0175.
DR KEGG; hpy:HP_0175; -.
DR PATRIC; fig|85962.47.peg.189; -.
DR eggNOG; COG0760; Bacteria.
DR OMA; YEQAKPT; -.
DR PhylomeDB; P56112; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR000297; PPIase_PpiC.
DR InterPro; IPR023058; PPIase_PpiC_CS.
DR InterPro; IPR027304; Trigger_fact/SurA_dom_sf.
DR Pfam; PF00639; Rotamase; 1.
DR SUPFAM; SSF109998; SSF109998; 1.
DR PROSITE; PS01096; PPIC_PPIASE_1; 1.
DR PROSITE; PS50198; PPIC_PPIASE_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Isomerase; Reference proteome; Rotamase; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..299
FT /note="Putative peptidyl-prolyl cis-trans isomerase
FT HP_0175"
FT /id="PRO_0000025547"
FT DOMAIN 154..253
FT /note="PpiC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
FT STRAND 44..48
FT /evidence="ECO:0007829|PDB:6BHF"
FT STRAND 51..54
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 55..57
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 70..72
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 75..97
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 100..102
FT /evidence="ECO:0007829|PDB:5EZ1"
FT HELIX 104..131
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 137..151
FT /evidence="ECO:0007829|PDB:6BHF"
FT STRAND 152..154
FT /evidence="ECO:0007829|PDB:6BHF"
FT STRAND 156..166
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 167..178
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 182..184
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 185..196
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 200..205
FT /evidence="ECO:0007829|PDB:6BHF"
FT STRAND 210..215
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 216..218
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 221..228
FT /evidence="ECO:0007829|PDB:6BHF"
FT STRAND 240..242
FT /evidence="ECO:0007829|PDB:6BHF"
FT STRAND 245..254
FT /evidence="ECO:0007829|PDB:6BHF"
FT HELIX 262..290
FT /evidence="ECO:0007829|PDB:6BHF"
SQ SEQUENCE 299 AA; 34031 MW; E65F3F2F94B11F5A CRC64;
MKKNILNLAL VGALSTSFLM AKPAHNANNA THNTKKTTDS SAGVLATVDG RPITKSDFDM
IKQRNPNFDF DKLKEKEKEA LIDQAIRTAL VENEAKTEKL DSTPEFKAMM EAVKKQALVE
FWAKKQAEEV KKVQIPEKEM QDFYNANKDQ LFVKQEAHAR HILVKTEDEA KRIISEIDKQ
PKAKKEAKFI ELANRDTIDP NSKNAQNGGD LGKFQKNQMA PDFSKAAFAL TPGDYTKTPV
KTEFGYHIIY LISKDSPVTY TYEQAKPTIK GMLQEKLFQE RMNQRIEELR KHAKIVINK
