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Y1760_DROME
ID   Y1760_DROME             Reviewed;        1093 AA.
AC   Q9VKA4; E1JHG5; Q8MT43;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 3.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Probable G-protein coupled receptor CG31760;
GN   ORFNames=CG31760;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=17372656; DOI=10.1039/b617545g;
RA   Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA   Eng J.K., Aebersold R., Tao W.A.;
RT   "An integrated chemical, mass spectrometric and computational strategy for
RT   (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT   Kc167 cells.";
RL   Mol. Biosyst. 3:275-286(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Isoform C is produced by readthrough of a stop codon between
CC         the codons for Val-875 and Arg-877. This is likely to be a rare event
CC         with most transcripts using the stop codon following Val-875.
CC         {ECO:0000305};
CC       Name=C {ECO:0000312|FlyBase:FBgn0051760};
CC         IsoId=Q9VKA4-3; Sequence=Displayed;
CC       Name=B {ECO:0000312|FlyBase:FBgn0051760}; Synonyms=D
CC       {ECO:0000312|FlyBase:FBgn0051760};
CC         IsoId=Q9VKA4-2; Sequence=VSP_058136;
CC   -!- MISCELLANEOUS: This protein is translated by readthrough of a stop
CC       codon. Readthrough of the terminator codon TAG occurs between the
CC       codons for Val-875 and Arg-877. There is currently no sequence that
CC       provides the identity of residue 876. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       {ECO:0000305}.
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DR   EMBL; AE014134; AAF53174.3; -; Genomic_DNA.
DR   EMBL; AE014134; ACZ94248.1; -; Genomic_DNA.
DR   EMBL; AE014134; AGB92937.1; -; Genomic_DNA.
DR   EMBL; AY118394; AAM48423.1; -; mRNA.
DR   RefSeq; NP_001162962.1; NM_001169491.2.
DR   RefSeq; NP_001260402.1; NM_001273473.2.
DR   RefSeq; NP_723730.2; NM_164996.3. [Q9VKA4-3]
DR   BioGRID; 60692; 1.
DR   IntAct; Q9VKA4; 2.
DR   STRING; 7227.FBpp0290241; -.
DR   TCDB; 9.A.14.15.2; the g-protein-coupled receptor (gpcr) family.
DR   GlyGen; Q9VKA4; 4 sites.
DR   iPTMnet; Q9VKA4; -.
DR   PaxDb; Q9VKA4; -.
DR   PRIDE; Q9VKA4; -.
DR   DNASU; 34642; -.
DR   EnsemblMetazoa; FBtr0331996; FBpp0304318; FBgn0051760. [Q9VKA4-3]
DR   GeneID; 34642; -.
DR   KEGG; dme:Dmel_CG31760; -.
DR   UCSC; CG31760-RA; d. melanogaster. [Q9VKA4-3]
DR   FlyBase; FBgn0051760; CG31760.
DR   VEuPathDB; VectorBase:FBgn0051760; -.
DR   eggNOG; KOG4418; Eukaryota.
DR   InParanoid; Q9VKA4; -.
DR   BioGRID-ORCS; 34642; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 34642; -.
DR   PRO; PR:Q9VKA4; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0051760; Expressed in brain and 7 other tissues.
DR   Genevisible; Q9VKA4; DM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR043458; GPR158/179.
DR   PANTHER; PTHR32546; PTHR32546; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1093
FT                   /note="Probable G-protein coupled receptor CG31760"
FT                   /id="PRO_0000372663"
FT   TOPO_DOM        1..51
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..512
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        513..533
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        534..547
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        548..568
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        569..584
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        585..607
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        608..619
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        620..640
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        641..660
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        661..681
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        682..701
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        702..722
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        723..730
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        731..751
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        752..1093
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          847..881
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        847..864
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         519
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:17372656"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        236
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        462
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        476
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         877..1093
FT                   /note="Missing (in isoform B)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_058136"
SQ   SEQUENCE   1093 AA;  121584 MW;  342587FD4C2B18C9 CRC64;
     MKCWHNVVRR RRKKPTAAAA AKGSKGSHGG VASPRDEDAI CQRQQQVDTY TWLTTQAVPL
     LWLHLLLLVA FAKHAAAATT IATNPEATTT TVSNYTVTTT ALSSSTTTTS SGSAPALSSA
     ADKFAGNWAN LEDSFRNIVR IGDGNTVTRT SIEQSLVTIH DIATENLGTL CISTLYRPLQ
     VPINSERYES SRQKTDLAAS ILQEVGIIRH GGLSDALAKG LLTDDFITGA RILALNLTNG
     AVQSYVWWVK GTAAEIQRYD EDGLQIGKKP AGSYPWFDDE TSSPTLRSPK FAPSPPNNYY
     KGWWTYPYFS CSQSRWLVSY SIAIPPIGRH GLRGFISIDI DVSTLRVNQC EAEPYPFGSR
     RQKMQQLQTH NRLGARRSLF LGSRMGAIDE STINDLQAFH SSHKCHRTSM VCDYRQPSAE
     TPTVTGGKLL TTLTGSSSWT RGSYQCLCRG GFYSLRHPDG FNGTIMEIAW QEQQDNISNY
     YSEVFKCLPC APGCDTCTGP EPCLANYHWP FRISLLTISI GCACGTFVLA GYLFRHRRVK
     VFKVASPIFL MITLIGCAIM YLEMVAIFPY LDTTWCIATK WTRHMGFCIT YTSLLMKTWR
     VSLTYRVKSA HKIKLNDQQL LQWMVPILLV MLIYLGTWTI SATPTAEVIL DQSQLKFKQC
     SYNWWDHSLA IGEVFFLAWG IRVCYNVRNA ESLYNEARLI SYAIYNIALV NIAMVVFHVM
     LFPNAGPDYK YMLGFVRTQL STTTTIALVF GPKILRVFKG QGDKWDQKAK VRSITASFSL
     NGVGLVPEES PDLYQENEEL KEQVQKLAHQ IEFMKTVHMQ MNNRHLKPKP GGYFTITSTS
     FQAPYSKNTV STAQTQTGKD ENSTPTKLKS PKGKVXRGQR SVKDCSIEID GGQGRTTLVE
     DAIEFNFHLA DTEKGLIVQE DERPGSDEEE AALIAQFRRL FAPILDDSLN LYYQLNDLDD
     TEHVRIHQTV AQMNDLTSSE EETMVTQVNS PSPPPVGVEL LLPISSDSST ASSSLYAIHT
     PSPAHPSGVL LMPQNLESPL LSGSDAITIT EQVELHNPPH HLQLLEDENN TSCSLSSNLT
     DSKTLDGRTP IVV
 
 
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