ID   Y1768_MYCBP             Reviewed;         312 AA.
AC   A1KJE6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase BCG_1768c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=BCG_1768c;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AM408590; CAL71755.1; -; Genomic_DNA.
DR   RefSeq; WP_003408497.1; NC_008769.1.
DR   AlphaFoldDB; A1KJE6; -.
DR   SMR; A1KJE6; -.
DR   KEGG; mbb:BCG_1768c; -.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; NPFRDHG; -.
DR   Proteomes; UP000001472; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..312
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase BCG_1768c"
FT                   /id="PRO_0000361141"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..160
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   312 AA;  33654 MW;  D0FA7184385E7FDE CRC64;
     MARTDDDNWD LTSSVGVTAT IVAVGRALAT KDPRGLINDP FAEPLVRAVG LDLFTKMMDG
     ELDMSTIADV SPAVAQAMVY GNAVRTKYFD DYLLNATAGG IRQVAILASG LDSRAYRLPW
     PTRTVVYEID QPKVMEFKTT TLADLGAEPS AIRRAVPIDL RADWPTALQA AGFDSAAPTA
     WLAEGLLIYL KPQTQDRLFD NITALSAPGS MVATEFVTGI ADFSAERART ISNPFRCHGV
     DVDLASLVYT GPRNHVLDYL AAKGWQPEGV SLAELFRRSG LDVRAADDDT IFISGCLTDH
     SSISPPTAAG WR