ID   Y1770_MYCTU             Reviewed;         312 AA.
AC   P9WFH9; L0T938; P71987; Q7D825;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv1729c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv1729c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44495.1; -; Genomic_DNA.
DR   PIR; D70687; D70687.
DR   RefSeq; NP_216245.1; NC_000962.3.
DR   RefSeq; WP_003408497.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WFH9; -.
DR   SMR; P9WFH9; -.
DR   STRING; 83332.Rv1729c; -.
DR   PaxDb; P9WFH9; -.
DR   DNASU; 885194; -.
DR   GeneID; 885194; -.
DR   KEGG; mtu:Rv1729c; -.
DR   TubercuList; Rv1729c; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; NPFRDHG; -.
DR   PhylomeDB; P9WFH9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..312
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Rv1729c"
FT                   /id="PRO_0000361237"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..160
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   312 AA;  33654 MW;  D0FA7184385E7FDE CRC64;
     MARTDDDNWD LTSSVGVTAT IVAVGRALAT KDPRGLINDP FAEPLVRAVG LDLFTKMMDG
     ELDMSTIADV SPAVAQAMVY GNAVRTKYFD DYLLNATAGG IRQVAILASG LDSRAYRLPW
     PTRTVVYEID QPKVMEFKTT TLADLGAEPS AIRRAVPIDL RADWPTALQA AGFDSAAPTA
     WLAEGLLIYL KPQTQDRLFD NITALSAPGS MVATEFVTGI ADFSAERART ISNPFRCHGV
     DVDLASLVYT GPRNHVLDYL AAKGWQPEGV SLAELFRRSG LDVRAADDDT IFISGCLTDH
     SSISPPTAAG WR