Y1784_ARCFU
ID Y1784_ARCFU Reviewed; 177 AA.
AC O28490;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Putative protein N5-glutamine methyltransferase AF_1784 {ECO:0000305};
DE EC=2.1.1.- {ECO:0000305};
DE AltName: Full=M.AfuHemKP;
GN OrderedLocusNames=AF_1784;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Putative protein methyltransferase using S-adenosyl-L-
CC methionine as the methyl donor. May methylate a Gln residue in target
CC proteins (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) +
CC N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:57452, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14895,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30011, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61891; Evidence={ECO:0000305};
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal PrmC-related family.
CC {ECO:0000305}.
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DR EMBL; AE000782; AAB89463.1; -; Genomic_DNA.
DR PIR; G69472; G69472.
DR RefSeq; WP_010879280.1; NC_000917.1.
DR AlphaFoldDB; O28490; -.
DR SMR; O28490; -.
DR STRING; 224325.AF_1784; -.
DR EnsemblBacteria; AAB89463; AAB89463; AF_1784.
DR GeneID; 24795527; -.
DR KEGG; afu:AF_1784; -.
DR eggNOG; arCOG00109; Archaea.
DR HOGENOM; CLU_018398_6_2_2; -.
DR OMA; EWDDWME; -.
DR OrthoDB; 72076at2157; -.
DR PhylomeDB; O28490; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0044260; P:cellular macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004557; PrmC-related.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR TIGRFAMs; TIGR00537; hemK_rel_arch; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..177
FT /note="Putative protein N5-glutamine methyltransferase
FT AF_1784"
FT /id="PRO_0000157175"
FT BINDING 30..34
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 51
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 86..89
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 86
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
SQ SEQUENCE 177 AA; 20041 MW; 12143379B026BD81 CRC64;
MIYEPAEDSE LLLEAALREL KPDDEVIEVG AGSGFVAERL KGKCKCILTT DISPFAAMEL
RRKGLDVVMT DIAKGIRKKF SLVLFNPPYV ELEDELRRGD WLDVAIDGGK KGVKVIKKFL
DSLDEIMAER GRAILIASSQ NEPDVFDLID ERGFRYEIVG ERGLFFEKLF AIKIWKE
