Y1790_ARATH
ID Y1790_ARATH Reviewed; 631 AA.
AC Q9C9V6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=BTB/POZ domain-containing protein At1g67900;
GN OrderedLocusNames=At1g67900; ORFNames=T23K23.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
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DR EMBL; AC012563; AAG52016.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34717.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34718.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34719.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60180.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60181.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60182.1; -; Genomic_DNA.
DR EMBL; AY120729; AAM53287.1; -; mRNA.
DR EMBL; BT008787; AAP68226.1; -; mRNA.
DR PIR; G96701; G96701.
DR RefSeq; NP_001185347.1; NM_001198418.1.
DR RefSeq; NP_001319340.1; NM_001334336.1.
DR RefSeq; NP_001322484.1; NM_001334338.1.
DR RefSeq; NP_001322485.1; NM_001334337.1.
DR RefSeq; NP_176957.1; NM_105460.6.
DR RefSeq; NP_974103.1; NM_202374.3.
DR AlphaFoldDB; Q9C9V6; -.
DR SMR; Q9C9V6; -.
DR STRING; 3702.AT1G67900.2; -.
DR iPTMnet; Q9C9V6; -.
DR PaxDb; Q9C9V6; -.
DR PRIDE; Q9C9V6; -.
DR ProteomicsDB; 243058; -.
DR EnsemblPlants; AT1G67900.1; AT1G67900.1; AT1G67900.
DR EnsemblPlants; AT1G67900.2; AT1G67900.2; AT1G67900.
DR EnsemblPlants; AT1G67900.3; AT1G67900.3; AT1G67900.
DR EnsemblPlants; AT1G67900.4; AT1G67900.4; AT1G67900.
DR EnsemblPlants; AT1G67900.5; AT1G67900.5; AT1G67900.
DR EnsemblPlants; AT1G67900.6; AT1G67900.6; AT1G67900.
DR GeneID; 843118; -.
DR Gramene; AT1G67900.1; AT1G67900.1; AT1G67900.
DR Gramene; AT1G67900.2; AT1G67900.2; AT1G67900.
DR Gramene; AT1G67900.3; AT1G67900.3; AT1G67900.
DR Gramene; AT1G67900.4; AT1G67900.4; AT1G67900.
DR Gramene; AT1G67900.5; AT1G67900.5; AT1G67900.
DR Gramene; AT1G67900.6; AT1G67900.6; AT1G67900.
DR KEGG; ath:AT1G67900; -.
DR Araport; AT1G67900; -.
DR TAIR; locus:2200286; AT1G67900.
DR eggNOG; ENOG502QSYM; Eukaryota.
DR HOGENOM; CLU_005994_5_2_1; -.
DR InParanoid; Q9C9V6; -.
DR OMA; WSISGLK; -.
DR OrthoDB; 510893at2759; -.
DR PhylomeDB; Q9C9V6; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9C9V6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9V6; baseline and differential.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF03000; NPH3; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..631
FT /note="BTB/POZ domain-containing protein At1g67900"
FT /id="PRO_0000409571"
FT DOMAIN 28..93
FT /note="BTB"
FT DOMAIN 200..509
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 361..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 450
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9FMF5"
FT MOD_RES 567
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
SQ SEQUENCE 631 AA; 70315 MW; 86A89CB8BA28FC54 CRC64;
MKFMKLGSRP DTFYTSEDLR CVSSEVSSDF TIEVSGSRYL LHKFPLLSKC LRLQRMCSES
PESIIQLPEF PGGVEAFELC AKFCYGITIT ISAYNIVAAR CAAEYLQMSE EVEKGNLVYK
LEVFFNSCIL NGWRDSIVTL QTTKAFPLWS EDLAITSRCI EAIASKVLSH PSKVSLSHSH
SRRVRDDDMS SNRAAASSRG WWAEDIAELG IDLYWRTMIA IKSGGKVPAS LIGDALRVYA
SKWLPTLQRN RKVVKKKEDS DSDSDTDTSS KHRLLLESII SLLPAEKGAV SCSFLLKLLK
AANILNASTS SKMELARRVA LQLEEATVSD LLIPPMSYKS ELLYDVDIVA TILEQFMVQG
QTSPPTSPLR GKKGMMDRRR RSRSAENIDL EFQESRRSSS ASHSSKLKVA KLVDGYLQQI
ARDVNLPLSK FVTLAESVPE FSRLDHDDLY RAIDIYLKAH KNLNKSERKR VCRVLDCKKL
SMEACMHAAQ NEMLPLRVVV QVLFYEQARA AAATNNGEKN TTELPSNIKA LLAAHNIDPS
NPNAAAFSTT TSIAAPEDRW SVSGLKSPKS KLSGTLRSKL AEDEEVDERF MNGDGGRTPS
RFKAFCAIPG RPKKMFSKLL SINRNSSDKN C
