ID   CAPSD_TPCTV             Reviewed;         242 AA.
AC   Q88886;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Capsid protein;
DE   AltName: Full=Coat protein;
DE            Short=CP;
GN   ORFNames=V1;
OS   Tomato pseudo-curly top virus (TPCTV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Topocuvirus.
OX   NCBI_TaxID=49267;
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8638404; DOI=10.1006/viro.1996.0264;
RA   Briddon R.W., Bedford I.D., Tsai J.H., Markham P.G.;
RT   "Analysis of the nucleotide sequence of the treehopper-transmitted
RT   geminivirus, tomato pseudo-curly top virus, suggests a recombinant
RT   origin.";
RL   Virology 219:387-394(1996).
CC   -!- FUNCTION: Encapsidates the viral genome into characteristic twinned
CC       ('geminate') particles. Binds the genomic viral ssDNA and shuttles it
CC       into and out of the cell nucleus. Plays a role in protection of the
CC       genome from degradation, virus acquisition and transmission by insect
CC       vectors, infectivity, and systemic movement. The CP of monopartite
CC       geminiviruses is absolutely essential for virus movement (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Binds to single-stranded and double-stranded
CC       viral DNA. Interacts (via nuclear localization signal) with host
CC       importin alpha-1a (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=It is actively transported into the host cell nucleus. It may be
CC       exported out of the nucleus through a nuclear export signal for cell-
CC       to-cell movement and spread (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; X84735; CAA59221.1; -; Genomic_DNA.
DR   RefSeq; NP_620732.1; NC_003825.1.
DR   SMR; Q88886; -.
DR   GeneID; 944410; -.
DR   KEGG; vg:944410; -.
DR   Proteomes; UP000007068; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR000263; GV_A/BR1_coat.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF00844; Gemini_coat; 1.
PE   3: Inferred from homology;
KW   Capsid protein; DNA-binding; Host nucleus; Reference proteome;
KW   T=1 icosahedral capsid protein; Viral penetration into host nucleus;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..242
FT                   /note="Capsid protein"
FT                   /id="PRO_0000323677"
FT   MOTIF           1..42
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   242 AA;  26922 MW;  263FB3C6E840EC71 CRC64;
     MPYKRKLTSY FPQSKRFRGA KSGMAVVKTS ASRRLYKKGK RKPDRIKTYT YAFSSICTDK
     GTIVYMNSWS LGLGPQQRSS DIEILKSMYI RLTVALSENA ASQVKTYVVK WALIVDQVPG
     ETLVGVADVY KTCPSPYPYV QCAYIADDNH SRFQVLRSGF LSLSGNGLAV GSSTRTGCPA
     MKNMASINKF CKNLNVRCVY DADSATGDIA SIKRGAVYLV IWPDVEIRYG FSCTMYHRNG
     NA