ID   Y1797_COREF             Reviewed;         421 AA.
AC   Q8FPI1;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Uncharacterized RNA methyltransferase CE1797;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=CE1797;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01024}.
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DR   EMBL; BA000035; BAC18607.1; -; Genomic_DNA.
DR   RefSeq; WP_006767794.1; NZ_GG700683.1.
DR   AlphaFoldDB; Q8FPI1; -.
DR   SMR; Q8FPI1; -.
DR   STRING; 196164.23493638; -.
DR   EnsemblBacteria; BAC18607; BAC18607; BAC18607.
DR   KEGG; cef:CE1797; -.
DR   eggNOG; COG2265; Bacteria.
DR   HOGENOM; CLU_014689_7_0_11; -.
DR   OMA; FYAGDMK; -.
DR   OrthoDB; 1421660at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR030390; MeTrfase_TrmA_AS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   PANTHER; PTHR11061; PTHR11061; 2.
DR   Pfam; PF01938; TRAM; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01230; TRMA_1; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..421
FT                   /note="Uncharacterized RNA methyltransferase CE1797"
FT                   /id="PRO_0000161975"
FT   DOMAIN          14..72
FT                   /note="TRAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00208"
FT   ACT_SITE        376
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         250
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         286
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         308
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         349
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
SQ   SEQUENCE   421 AA;  44574 MW;  0EA965AAEEF0E224 CRC64;
     MSDTAELTTD PTPDLTKGDT ITVEVTRPAH GGEGIAHHGG RVIFVRGGFP GDDVDVEITQ
     VKKRFARGFV VQVNVASPHR VDSRCPAAAA GAGCCDYAEL SPEAELEIKS RVLTDQLQRI
     GGLADIPTPE LFELEPSQGW RTRVRLGVDA SGRAGFRKLR SNDLVTDVAC SQVVPELIDG
     LVGPGARTFT PDSEVIAAID DRGVRTVVEV RKAPRGRRAE TILHVLEGDG SVEQTVGDHT
     WTFPVSGFWQ AHTKAPGAYS AFIGEVLDGA ELVDVDKRGP VAWDLYGGVG LFVPVINRAL
     GAHVHSVELS EGSAEAGDDA LAGLPVTFHA GRVESVTSQL PKPHVVVLDP PRTGAGSDVV
     ATIAGAKPQL VVHIGCDPAT FARDVADWSA GGYTLDRLAV FNAFPATHHY ETIGVFTRKS
     A