Y1801_ARATH
ID Y1801_ARATH Reviewed; 138 AA.
AC Q9SSC1;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=MAPK kinase substrate protein At1g80180;
GN OrderedLocusNames=At1g80180 {ECO:0000312|Araport:AT1G80180};
GN ORFNames=F18B13.26 {ECO:0000312|EMBL:AAD55474.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-105, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [6]
RP FUNCTION, PHOSPHORYLATION AT SER-105, TISSUE SPECIFICITY, AND MUTAGENESIS
RP OF SER-105.
RX PubMed=22631074; DOI=10.1042/bj20111809;
RA Soerensson C., Lenman M., Veide-Vilg J., Schopper S., Ljungdahl T.,
RA Groetli M., Tamas M.J., Peck S.C., Andreasson E.;
RT "Determination of primary sequence specificity of Arabidopsis MAPKs MPK3
RT and MPK6 leads to identification of new substrates.";
RL Biochem. J. 446:271-278(2012).
CC -!- FUNCTION: May play a role in the regulation of stomata patterning.
CC {ECO:0000305|PubMed:22631074}.
CC -!- TISSUE SPECIFICITY: Expressed in developing cotyledons, mature
CC cotyledons, cotyledon epidermis and stomata.
CC {ECO:0000269|PubMed:22631074}.
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DR EMBL; AC009322; AAD55474.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE36367.1; -; Genomic_DNA.
DR EMBL; AY039872; AAK63976.1; -; mRNA.
DR EMBL; AY077663; AAL76141.1; -; mRNA.
DR EMBL; AY087473; AAM65017.1; -; mRNA.
DR PIR; E96833; E96833.
DR RefSeq; NP_565233.1; NM_106667.3.
DR AlphaFoldDB; Q9SSC1; -.
DR STRING; 3702.AT1G80180.1; -.
DR iPTMnet; Q9SSC1; -.
DR PaxDb; Q9SSC1; -.
DR PRIDE; Q9SSC1; -.
DR ProMEX; Q9SSC1; -.
DR ProteomicsDB; 232468; -.
DR EnsemblPlants; AT1G80180.1; AT1G80180.1; AT1G80180.
DR GeneID; 844358; -.
DR Gramene; AT1G80180.1; AT1G80180.1; AT1G80180.
DR KEGG; ath:AT1G80180; -.
DR Araport; AT1G80180; -.
DR TAIR; locus:2016264; AT1G80180.
DR HOGENOM; CLU_123547_1_0_1; -.
DR InParanoid; Q9SSC1; -.
DR OMA; NEHKGET; -.
DR OrthoDB; 1512113at2759; -.
DR PhylomeDB; Q9SSC1; -.
DR PRO; PR:Q9SSC1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SSC1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0010375; P:stomatal complex patterning; IMP:TAIR.
DR InterPro; IPR031421; DUF4666.
DR PANTHER; PTHR33730; PTHR33730; 1.
DR Pfam; PF15697; DUF4666; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..138
FT /note="MAPK kinase substrate protein At1g80180"
FT /id="PRO_0000439062"
FT REGION 52..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..138
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
FT MOD_RES 105
FT /note="Phosphoserine; by MAPK6"
FT /evidence="ECO:0000269|PubMed:22631074,
FT ECO:0007744|PubMed:19376835"
FT MUTAGEN 105
FT /note="S->A: Loss of phosphorylation by MAPK6."
FT /evidence="ECO:0000269|PubMed:22631074"
FT MUTAGEN 105
FT /note="S->D: Clustered stomata and high stomatal index in
FT cotyledons."
FT /evidence="ECO:0000269|PubMed:22631074"
SQ SEQUENCE 138 AA; 15106 MW; BABBAAE8D1AD60EB CRC64;
MAGLQRSTIS FRRQGSSGIV WDDRLIAELS QQAANDRKGE TLQQDEQAKL ITSEVQDQTT
KPIAGEGLKP IRTDGGMERS RSNGGGAIRH HRNTGRVSPA VDPPSPRLSA FGCCSAFGKK
QPGKKVNQRK RPAKRRSR
