Y1806_DICDI
ID Y1806_DICDI Reviewed; 1167 AA.
AC Q55AN8; Q86HH0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=PH and Rap-GAP domain-containing protein DDB_G0271806;
GN ORFNames=DDB_G0271806;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AAFI02000006; EAL71593.1; -; Genomic_DNA.
DR RefSeq; XP_645484.1; XM_640392.1.
DR AlphaFoldDB; Q55AN8; -.
DR SMR; Q55AN8; -.
DR STRING; 44689.DDB0229869; -.
DR PaxDb; Q55AN8; -.
DR PRIDE; Q55AN8; -.
DR EnsemblProtists; EAL71593; EAL71593; DDB_G0271806.
DR GeneID; 8618112; -.
DR KEGG; ddi:DDB_G0271806; -.
DR dictyBase; DDB_G0271806; rapgap3.
DR eggNOG; KOG3686; Eukaryota.
DR HOGENOM; CLU_274579_0_0_1; -.
DR InParanoid; Q55AN8; -.
DR OMA; QVGNDIC; -.
DR Reactome; R-DDI-392517; Rap1 signalling.
DR PRO; PR:Q55AN8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0031254; C:cell trailing edge; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0070685; C:macropinocytic cup; IDA:dictyBase.
DR GO; GO:0044354; C:macropinosome; IDA:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR GO; GO:0031143; C:pseudopodium; IDA:dictyBase.
DR GO; GO:0005096; F:GTPase activator activity; IMP:dictyBase.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:dictyBase.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:dictyBase.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IDA:dictyBase.
DR GO; GO:0034260; P:negative regulation of GTPase activity; IMP:dictyBase.
DR GO; GO:0043087; P:regulation of GTPase activity; IMP:dictyBase.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IMP:dictyBase.
DR GO; GO:1903013; P:response to differentiation-inducing factor 1; HDA:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IDA:dictyBase.
DR GO; GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.
DR Gene3D; 2.30.29.30; -; 3.
DR Gene3D; 3.40.50.11210; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF111347; SSF111347; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation; Reference proteome; Repeat.
FT CHAIN 1..1167
FT /note="PH and Rap-GAP domain-containing protein
FT DDB_G0271806"
FT /id="PRO_0000368232"
FT DOMAIN 35..140
FT /note="PH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 165..257
FT /note="PH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 950..1162
FT /note="Rap-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00165"
FT REGION 95..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 130198 MW; 4378D79F49804D98 CRC64;
MHTGEYSELL IGINGHMKKI TLKLKNNLEE DQYSNCVKYG WIEKRCGKNQ SFSSWKRMWF
ILKDSKLTYY IKEKNLKKRS STIGSTQEFF KQQHGIDNNN CTNSNSNNNN NNSDLIHLSA
PSLSSSTSST ISPISSSSSL TTTTTTTTTT TNANTNNGLS DSINHVYLEG ELGKKKEGKG
WKVRWMKLLE HSLVYYKSSK DKEPLGIVNL NECQDCEVNK ESSNKFVVVH SSNRYYFKTN
TKQELTQWVK SVKSRIPSIN QTKMDLDQFQ LKGVIEFNSI QQIAETFKFN SQPNCLTITT
DEKAYYLSFD SNKDKLDWLN QLNLTINKFK GGFNSGGGSN NSSPSSLQSQ QAKESGNGGS
LSPNILGNFK SSIKPWRFSS SPSQGRVSIG GGGDRSSTQV KFVDNPLSKS SNKEEFDGGE
YGSQILPRKS TIIGPNGGVK VSTSGAVELS PVLISSNNNN NNTISSSGNS IPTCLSDLIN
ESSDNEDGDD LKMMIPESLK NEMMRRSAIS SLKNFKLEIF IWSNHQEVFT FLFSDSVLVD
QVKAFAFKKI PSLANLSVLD YRLGIDEDTL LEVEFLKFIY SHTMVELALK TCGIVKIGIF
HHRKDRRVKE KLYSDKFYGH LLSQSPDGRK GNGVGIGGNG IPIEYSRSEP NLQSCLSSSP
STRETMVPSS PSSHQLITPP PSLKQYEQQL SSSSSSSSQQ LQLQLQQQEQ EQLLQEQPEA
EQSQPEPQPQ LEPESEIEIE ELEQPIEELL NISTTPISIR SNSILSSSTS ASSSPSSTPS
LTPVIERQQK MSAAGWHSVN PSVTLNQRRQ LISGCPGWNI EVSNPTSTFT SQGFKPKFDK
QEHGFYRRYN FDGTSTVQSF LGVDMKMGPL AFSLAKDAND NYRGVLHTKH GAKTISEDSK
NIVGILNLLS LSKKVKTKKV VSHLIGLLDP SIDAKLLNLA SNQSELQKEL LSFEERQTTS
GFKFGMVYCR HGQVTDDEIF SNKQGSPEWD EFLSLIGDKI ELVGWPHYSA GLDVKFNSTG
THSLYTDYHG NEVMFHVSTM LPFSTTDYQQ IERKRQVGND ICVVIFNDGT LSYMPNTITS
QFNHVIILVQ YDKQNNGYKV SMACKDGVKS PFEPLSPNNL IKKSDIKDFI LTKLINGELA
SLQAPVFASK ITRTRESLLN YYISQFL
