ID   Y1808_MYCLB             Reviewed;         335 AA.
AC   B8ZS82;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=UPF0353 protein MLBr01808 {ECO:0000255|HAMAP-Rule:MF_01340};
GN   OrderedLocusNames=MLBr01808;
OS   Mycobacterium leprae (strain Br4923).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=561304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Br4923;
RX   PubMed=19881526; DOI=10.1038/ng.477;
RA   Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A.,
RA   Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C.,
RA   Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H.,
RA   Vera-Cabrera L., Stefani M.M., Banu S., Macdonald M., Sapkota B.R.,
RA   Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A.,
RA   Rougemont J., Brennan P.J., Cole S.T.;
RT   "Comparative genomic and phylogeographic analysis of Mycobacterium
RT   leprae.";
RL   Nat. Genet. 41:1282-1289(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01340};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01340}.
CC   -!- SIMILARITY: Belongs to the UPF0353 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01340}.
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DR   EMBL; FM211192; CAR71903.1; -; Genomic_DNA.
DR   RefSeq; WP_010908550.1; NC_011896.1.
DR   AlphaFoldDB; B8ZS82; -.
DR   SMR; B8ZS82; -.
DR   EnsemblBacteria; CAR71903; CAR71903; MLBr01808.
DR   KEGG; mlb:MLBr01808; -.
DR   HOGENOM; CLU_024570_2_0_11; -.
DR   OMA; RYFRATD; -.
DR   OrthoDB; 736429at2; -.
DR   Proteomes; UP000006900; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 1.
DR   HAMAP; MF_01340; UPF0353; 1.
DR   InterPro; IPR022933; UPF0353.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="UPF0353 protein MLBr01808"
FT                   /id="PRO_1000166266"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   DOMAIN          98..294
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
SQ   SEQUENCE   335 AA;  36100 MW;  674C99664F877580 CRC64;
     MTLPLLGPMS LSGFEHSWFF LFIFIVFGLA AFYVMMQVAR QRRMLRFANM ELLESVAPNR
     PVQWRHVPAI LLMLALLLFT IAMAGPTNDV RIPRNRAVVM LVIDVSQSMR ATDVEPNRMA
     AAQEAAKQFA GELTPGINLG LIAYAGTATV LVSPTTNRYA TKNALDKLQF ADRTATGEAI
     FTALQAIATV GAVIGGGEMP PPARIVLFSD GKETMPTNPD NPKGAYTAAR TAKDQGVPIS
     TISFGTVYGF VEINGQRQPV PVDDETMKKV AQLSGGNSYN AATLAELKAV YASLQQQIGY
     ETIKGDASAG WLRLGVLVLA LAALTALLIN RRLPT