ID   Y1808_PYRHO             Reviewed;         315 AA.
AC   O59472;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2002, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Putative HTH-type transcriptional regulatory protein PH1808 {ECO:0000255|HAMAP-Rule:MF_00584};
GN   OrderedLocusNames=PH1808;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA30927.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000001; BAA30927.1; ALT_INIT; Genomic_DNA.
DR   PIR; H71191; H71191.
DR   RefSeq; WP_048053613.1; NC_000961.1.
DR   AlphaFoldDB; O59472; -.
DR   SMR; O59472; -.
DR   STRING; 70601.3258244; -.
DR   EnsemblBacteria; BAA30927; BAA30927; BAA30927.
DR   GeneID; 1442650; -.
DR   KEGG; pho:PH1808; -.
DR   eggNOG; arCOG04152; Archaea.
DR   OMA; PGVVYFR; -.
DR   OrthoDB; 76134at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   HAMAP; MF_00584; HTH_type_cro_C1; 1.
DR   InterPro; IPR020886; Arc_TR_HTH.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..315
FT                   /note="Putative HTH-type transcriptional regulatory protein
FT                   PH1808"
FT                   /id="PRO_0000144863"
FT   DOMAIN          131..189
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00584"
FT   DNA_BIND        142..161
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00584"
SQ   SEQUENCE   315 AA;  35657 MW;  2FC9342421984443 CRC64;
     MERNELVNFV EGILKRIGFR TMKLEFRGGC FDLVATRQLL LLFIKALANI DKFSEEQAED
     LKKLAKLFKA SPLLVGLRSK NAELEDGVVY ERFGIYAITP GTLYSMFAEG EPPLIIAERG
     GFYVRIDGKK LKALREEHGY SITELAGILG ISRKSLQRYE KGESVVSLEV ALRLEEVFDE
     PLVKPIDVLR ARLKDVTLTS EPDNILEKEV FEKLRKLGMS VVKIKTAPFN AITKEEEDDI
     ELLTGIDERK TGRTLKRAEL VSQMAEVVGS DGVFVVKKAR MEVVRNVPIL PKKLLEEIKD
     ADELLELIRD LKFKS