Y1809_DICDI
ID Y1809_DICDI Reviewed; 1619 AA.
AC Q54TK4;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Rap-GAP domain-containing protein DDB_G0281809;
GN ORFNames=DDB_G0281809;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000042; EAL66666.1; -; Genomic_DNA.
DR RefSeq; XP_640587.1; XM_635495.1.
DR AlphaFoldDB; Q54TK4; -.
DR STRING; 44689.DDB0233080; -.
DR PaxDb; Q54TK4; -.
DR EnsemblProtists; EAL66666; EAL66666; DDB_G0281809.
DR GeneID; 8623196; -.
DR KEGG; ddi:DDB_G0281809; -.
DR dictyBase; DDB_G0281809; -.
DR eggNOG; KOG3652; Eukaryota.
DR eggNOG; KOG3686; Eukaryota.
DR HOGENOM; CLU_243625_0_0_1; -.
DR InParanoid; Q54TK4; -.
DR OMA; WCDGKIL; -.
DR PhylomeDB; Q54TK4; -.
DR PRO; PR:Q54TK4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; -; 1.
DR InterPro; IPR039930; RALGAPB.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR21344; PTHR21344; 2.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; SSF111347; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil; GTPase activation; Reference proteome.
FT CHAIN 1..1619
FT /note="Rap-GAP domain-containing protein DDB_G0281809"
FT /id="PRO_0000368233"
FT DOMAIN 1273..1494
FT /note="Rap-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00165"
FT REGION 128..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1554..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 265..295
FT /evidence="ECO:0000255"
FT COMPBIAS 289..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1619 AA; 180877 MW; 8D4A7D950E489E0A CRC64;
MITNSFTNNF QFIKDTGILK DFPLSVKRIL VFQTVNFLLE PPNGNTQFIV TSKEHLQWIM
EITEQGFLLP IEDSQIILQC IELYKKWLFD PKHKPTPLID DDDEYFHKKI IEHLTLIFQP
RSYPHYISMS NNNSNNNSNN SNININNNNN NNNNNNNNNN NNNNNNNNNN SNNTNSGSNN
KESSNNNSPI LSSSNSGSGS SLSLNKDKEG GGSNSGSFLG VNQQSSPPPQ QISATTTAAT
SPTTPTTPIK DTLQQQFLQQ EVGGFNEVVQ QQQQQQQQQQ QQQQQQQQQQ QQQQSPSITT
GTVKGSKYRE SVMPGSSMMV QSSTTALYSS NNYSGNVQLP NISVKELIDS HSVLCQKVLQ
IYLEMSRGTY SRSFSTDTLE HWNRLMLSIT DCILGIHSNS DEMLARNLCP LLLKTLFEVW
LQSKTLNPTL WNSLTKYAQG WFHHMPTVNQ WNLTCLALTT PLVQSIYTND HQSKSTITIR
LDETSIEFEK EYLYYAWNRI LNLIGNPNQI KSPAIFSEAI TGIFHLVSMF LSVTNDGNAI
LHIFGSWIFE AVKTIKPGFD EGISLGSEIL LHIFLSCSRK IEFLPIYLSC FYTCISEALW
CDGKILRDTI IHSQNIFSSG LPGSRILIPS YIRALNHILT AQGTNDPELR RCAIKILGSI
LCLPNRYETV KFHNFFPGRT IDPYPPLPND IIDGKHNELT LPPNEINTYD DLKPHLAYLI
LSALNTEMSS SNLLTLIWYI MFYQLEYQHQ HVKPYPDGKL ITSSFIHQSI NTILKKCSSF
TNQWSHDVIL SSFQLLSDLA SQHQRIPNFL ENASTVVRKL CKFITFKCKE TNMSPETEDL
ISLGCSTIAD WVVVSPWIFE GNYLTDTSTF YMVFNALSVA MGAKSPNDII SSNASISSSV
SNTGISSIGG GGSSGSGNSS QPSSTGSGSG GVDSGSKSNS SSSSSSQPSS TGGSGNNSNS
ANGGSFKRPK PYINNNISPK VKEVAQCALK AIMSKISYFP NPYNATPTNT SSKVTESDII
TQIKAKAEKH LGIKNFPSEQ SLRFYAIGDS IIITVIDQPF TSTSSSPSDS YVTLIIRDMS
GKSVINSQLA FLPFKQREIS EIQQPITNEK ESQIDDGDDS VPTNTTATTI DNTISNNNTT
TTSNNSIKST SNNKVPIKKR SQYNCNEEPF ISSYIENVED FGDLSSYIEK HIDENFTKLI
DNQMEVEKQK LFANKYSLTP SITTHPPVLK TSFNGDCKLQ QARILLTHLG FLNQENRNKL
TPLENSVQFF QSLNMLDSVS ERVQIKIPII YVKKGDSTED DIYNNVTSNT TQDYQDFIAS
LGWLVPISTH TGFLGDLDKK NLTHGQFTPY YATHSREMVF FVSTMMPNSD IANNSSQEHK
KKLINKTNVS VIWFNGSIEV YEKTLLETFP HAIQIVITPL ENDLFRLKTL RKATHSNRMK
TGPVNDEIII SKHILANVIR LSVVNSNQSL LNLSSGDGKT QHIYTNRKKL ISDITESFKH
DMTIQKFYEF HFEPLDQSQL YQNTENLPMA NNFKFVKTSS VNLFRKDRTQ SALIGTFTLP
PPPISPTISP QPSPHLSSSG GSWASSKGGS TQPTTPSGRT SNFLSRRPNL SQSEDQSHK
