ID   Y1812_MYCTO             Reviewed;         400 AA.
AC   P9WJJ0; L0T7Z1; O07220; Q8VJV9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=NADH dehydrogenase-like protein MT1860;
DE            EC=1.6.-.-;
GN   OrderedLocusNames=MT1860;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
CC   -!- SIMILARITY: Belongs to the NADH dehydrogenase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46133.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46133.1; ALT_INIT; Genomic_DNA.
DR   PIR; F70982; F70982.
DR   RefSeq; WP_003409193.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJJ0; -.
DR   SMR; P9WJJ0; -.
DR   EnsemblBacteria; AAK46133; AAK46133; MT1860.
DR   KEGG; mtc:MT1860; -.
DR   PATRIC; fig|83331.31.peg.2003; -.
DR   HOGENOM; CLU_021377_8_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003954; F:NADH dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006116; P:NADH oxidation; IEA:InterPro.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR045024; NDH-2.
DR   PANTHER; PTHR43706; PTHR43706; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN           1..400
FT                   /note="NADH dehydrogenase-like protein MT1860"
FT                   /id="PRO_0000427821"
SQ   SEQUENCE   400 AA;  41940 MW;  58A99134E1381A5C CRC64;
     MTRVVVIGSG FAGLWAALGA ARRLDELAVP AGTVDVMVVS NKPFHDIRVR NYEADLSACR
     IPLGDVLGPA GVAHVTAEVT AIDADGRRVT TSTGASYSYD RLVLASGSHV VKPALPGLAE
     FGFDVDTYDG AVRLQQHLQG LAGGPLTSAA ATVVVVGAGL TGIETACELP GRLHALFARG
     DGVTPRVVLI DHNPFVGSDM GLSARPVIEQ ALLDNGVETR TGVSVAAVSP GGVTLSSGER
     LAAATVVWCA GMRASRLTEQ LPVARDRLGR LQVDDYLRVI GVPAMFAAGD VAAARMDDEH
     LSVMSCQHGR PMGRYAGCNV INDLFDQPLL ALRIPWYVTV LDLGSAGAVY TEGWERKVVS
     QGAPAKTTKQ SINTRRIYPP LNGSRADLLA AAAPRVQPRP