Y1813_MYCTU
ID Y1813_MYCTU Reviewed; 143 AA.
AC P9WLS1; L0TAP3; P64889; Q50620;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Uncharacterized protein Rv1813c;
DE Flags: Precursor;
GN OrderedLocusNames=Rv1813c; ORFNames=MTCY1A11.30, MTY16F9.01;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION BY HYPOXIA.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=11416222; DOI=10.1073/pnas.121172498;
RA Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA Schoolnik G.K.;
RT "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT encoding alpha -crystallin.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN [3]
RP INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=12953092; DOI=10.1084/jem.20030205;
RA Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA Sherman D.R., Schoolnik G.K.;
RT "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT tuberculosis dormancy program.";
RL J. Exp. Med. 198:705-713(2003).
RN [4]
RP INDUCTION BY CARBON MONOXIDE (CO).
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
RA Shiloh M.U., Manzanillo P., Cox J.S.;
RT "Mycobacterium tuberculosis senses host-derived carbon monoxide during
RT macrophage infection.";
RL Cell Host Microbe 3:323-330(2008).
RN [5]
RP INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA Agarwal A., Steyn A.J.;
RT "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT tuberculosis dormancy regulon.";
RL J. Biol. Chem. 283:18032-18039(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC carbon monoxide (CO). It is hoped that this regulon will give insight
CC into the latent, or dormant phase of infection.
CC {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092,
CC ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359}.
CC -!- SIMILARITY: To M.tuberculosis Rv1269c. {ECO:0000305}.
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DR EMBL; AL123456; CCP44579.1; -; Genomic_DNA.
DR PIR; G70982; G70982.
DR RefSeq; NP_216329.1; NC_000962.3.
DR RefSeq; WP_003409199.1; NZ_NVQJ01000070.1.
DR PDB; 7NHZ; NMR; -; A=28-143.
DR PDBsum; 7NHZ; -.
DR AlphaFoldDB; P9WLS1; -.
DR SMR; P9WLS1; -.
DR STRING; 83332.Rv1813c; -.
DR PaxDb; P9WLS1; -.
DR DNASU; 885546; -.
DR GeneID; 45425788; -.
DR GeneID; 885546; -.
DR KEGG; mtu:Rv1813c; -.
DR TubercuList; Rv1813c; -.
DR eggNOG; ENOG502ZK3D; Bacteria.
DR OMA; WIETWAC; -.
DR Proteomes; UP000001584; Chromosome.
DR InterPro; IPR025240; DUF4189.
DR Pfam; PF13827; DUF4189; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..143
FT /note="Uncharacterized protein Rv1813c"
FT /id="PRO_0000103898"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:7NHZ"
FT STRAND 58..64
FT /evidence="ECO:0007829|PDB:7NHZ"
FT TURN 65..67
FT /evidence="ECO:0007829|PDB:7NHZ"
FT STRAND 68..76
FT /evidence="ECO:0007829|PDB:7NHZ"
FT HELIX 78..89
FT /evidence="ECO:0007829|PDB:7NHZ"
FT STRAND 98..109
FT /evidence="ECO:0007829|PDB:7NHZ"
FT STRAND 112..120
FT /evidence="ECO:0007829|PDB:7NHZ"
FT HELIX 121..131
FT /evidence="ECO:0007829|PDB:7NHZ"
FT STRAND 134..142
FT /evidence="ECO:0007829|PDB:7NHZ"
SQ SEQUENCE 143 AA; 14981 MW; 7CEB0DA60F7981B2 CRC64;
MITNLRRRTA MAAAGLGAAL GLGILLVPTV DAHLANGSMS EVMMSEIAGL PIPPIIHYGA
IAYAPSGASG KAWHQRTPAR AEQVALEKCG DKTCKVVSRF TRCGAVAYNG SKYQGGTGLT
RRAAEDDAVN RLEGGRIVNW ACN
