ID   Y1816_MYCTO             Reviewed;         234 AA.
AC   P9WMC8; L0T7S4; P67438; Q50617;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT1864;
GN   OrderedLocusNames=MT1864;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46137.1; -; Genomic_DNA.
DR   PIR; A70720; A70720.
DR   RefSeq; WP_003409205.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMC8; -.
DR   SMR; P9WMC8; -.
DR   EnsemblBacteria; AAK46137; AAK46137; MT1864.
DR   KEGG; mtc:MT1864; -.
DR   PATRIC; fig|83331.31.peg.2007; -.
DR   HOGENOM; CLU_069356_9_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR025996; TetR_C_WHG.
DR   Pfam; PF13305; TetR_C_33; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Membrane; Transcription; Transcription regulation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..234
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT1864"
FT                   /id="PRO_0000427326"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          15..75
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   234 AA;  25353 MW;  E67840A7C7B671C8 CRC64;
     MCQTCRVGKR RDAREQIEAK IVELGRRQLL DHGAAGLSLR AIARNLGMVS SAVYRYVSSR
     DELLTLLLVD AYSDLADTVD RARDDTVADS WSDDVIAIAR AVRGWAVTNP ARWALLYGSP
     VPGYHAPPDR TAGVATRVVG AFFDAIAAGI ATGDIRLTDD VAPQPMSSDF EKIRQEFGFP
     GDDRVVTKCF LLWAGVVGAI SLEVFGQYGA DMLTDPGVVF DAQTRLLVAV LAEH