Y1816_MYCTU
ID Y1816_MYCTU Reviewed; 234 AA.
AC P9WMC9; L0T7S4; P67438; Q50617;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv1816;
GN OrderedLocusNames=Rv1816; ORFNames=MTCY1A11.27c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=15375142; DOI=10.1128/jb.186.19.6605-6616.2004;
RA Raman S., Hazra R., Dascher C.C., Husson R.N.;
RT "Transcription regulation by the Mycobacterium tuberculosis alternative
RT sigma factor SigD and its role in virulence.";
RL J. Bacteriol. 186:6605-6616(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Positively regulated by alternative sigma factor SigD.
CC {ECO:0000269|PubMed:15375142}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL123456; CCP44582.1; -; Genomic_DNA.
DR PIR; A70720; A70720.
DR RefSeq; NP_216332.1; NC_000962.3.
DR RefSeq; WP_003409205.1; NC_000962.3.
DR PDB; 5D1R; X-ray; 2.00 A; A/B=1-234.
DR PDBsum; 5D1R; -.
DR AlphaFoldDB; P9WMC9; -.
DR SMR; P9WMC9; -.
DR STRING; 83332.Rv1816; -.
DR PaxDb; P9WMC9; -.
DR DNASU; 885340; -.
DR GeneID; 45425791; -.
DR GeneID; 885340; -.
DR KEGG; mtu:Rv1816; -.
DR TubercuList; Rv1816; -.
DR eggNOG; COG1309; Bacteria.
DR OMA; AKCFLLW; -.
DR PhylomeDB; P9WMC9; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR025996; TetR_C_WHG.
DR Pfam; PF13305; TetR_C_33; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Membrane; Reference proteome; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT CHAIN 1..234
FT /note="Uncharacterized HTH-type transcriptional regulator
FT Rv1816"
FT /id="PRO_0000070666"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 15..75
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT HELIX 14..32
FT /evidence="ECO:0007829|PDB:5D1R"
FT TURN 33..36
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 39..45
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 50..53
FT /evidence="ECO:0007829|PDB:5D1R"
FT TURN 54..56
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 60..84
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 91..108
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 110..117
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 128..131
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 134..136
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 137..151
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 166..177
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 183..204
FT /evidence="ECO:0007829|PDB:5D1R"
FT STRAND 210..212
FT /evidence="ECO:0007829|PDB:5D1R"
FT HELIX 216..231
FT /evidence="ECO:0007829|PDB:5D1R"
SQ SEQUENCE 234 AA; 25353 MW; E67840A7C7B671C8 CRC64;
MCQTCRVGKR RDAREQIEAK IVELGRRQLL DHGAAGLSLR AIARNLGMVS SAVYRYVSSR
DELLTLLLVD AYSDLADTVD RARDDTVADS WSDDVIAIAR AVRGWAVTNP ARWALLYGSP
VPGYHAPPDR TAGVATRVVG AFFDAIAAGI ATGDIRLTDD VAPQPMSSDF EKIRQEFGFP
GDDRVVTKCF LLWAGVVGAI SLEVFGQYGA DMLTDPGVVF DAQTRLLVAV LAEH
