ID   Y181_THEKO              Reviewed;         350 AA.
AC   Q5JFL6;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=UPF0219 protein TK0181 {ECO:0000255|HAMAP-Rule:MF_01409};
GN   OrderedLocusNames=TK0181;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. UPF0219 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01409}.
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DR   EMBL; AP006878; BAD84370.1; -; Genomic_DNA.
DR   RefSeq; WP_011249136.1; NC_006624.1.
DR   AlphaFoldDB; Q5JFL6; -.
DR   SMR; Q5JFL6; -.
DR   STRING; 69014.TK0181; -.
DR   EnsemblBacteria; BAD84370; BAD84370; TK0181.
DR   GeneID; 3234194; -.
DR   KEGG; tko:TK0181; -.
DR   PATRIC; fig|69014.16.peg.181; -.
DR   eggNOG; arCOG01767; Archaea.
DR   HOGENOM; CLU_039592_7_0_2; -.
DR   InParanoid; Q5JFL6; -.
DR   OMA; YAKHKGK; -.
DR   OrthoDB; 12601at2157; -.
DR   PhylomeDB; Q5JFL6; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IBA:GO_Central.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IBA:GO_Central.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 1.
DR   HAMAP; MF_01409; UPF0219; 1.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004656; FabH-rel.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR00748; HMG_CoA_syn_Arc; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..350
FT                   /note="UPF0219 protein TK0181"
FT                   /id="PRO_0000057624"
SQ   SEQUENCE   350 AA;  38072 MW;  435686533AD577EE CRC64;
     MSKLLKPKRE VGIIGYGAYV PMYRIKAEEI GRVWGVSSFP IQEKSVPGLD EDTITIGIEA
     ARNALKRAQI DPKLIRAIWL GTESKPYAVK PSGTVIAEAI GATPDLDAAD FEFACKAGTE
     AIQAAIGFVG SGMADYAMAI GADTSQGRPG DHLEFTAAAG GAAYILAPKS SETLAYFEAS
     YSYVTDTPDF WRRQHEHYPR HGNRFTGEPA YFHQIINAAK TLMEELGYTP NDFDYAVFHQ
     PNVKFPLTAA KILGFPKEKV LPGLLSGIIG NTYSGATLVG VSAVLDIAKP GDRILWVSFG
     SGAGSDAFSL VVQDAIEEKR DLAPKTMDYV NRKKYIDYAL YAKHRGKYIL