ID   Y1823_MYCTU             Reviewed;         307 AA.
AC   P9WFG1; L0TAQ3; P64891; Q50610;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=UPF0749 protein Rv1823;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv1823; ORFNames=MTCY1A11.20c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0749 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44589.1; -; Genomic_DNA.
DR   PIR; H70720; H70720.
DR   RefSeq; NP_216339.1; NC_000962.3.
DR   RefSeq; WP_003901262.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WFG1; -.
DR   SMR; P9WFG1; -.
DR   STRING; 83332.Rv1823; -.
DR   PaxDb; P9WFG1; -.
DR   DNASU; 885547; -.
DR   GeneID; 45425797; -.
DR   GeneID; 885547; -.
DR   KEGG; mtu:Rv1823; -.
DR   TubercuList; Rv1823; -.
DR   eggNOG; COG3879; Bacteria.
DR   OMA; RVRDRDM; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR010273; DUF881.
DR   PANTHER; PTHR37313; PTHR37313; 1.
DR   Pfam; PF05949; DUF881; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..307
FT                   /note="UPF0749 protein Rv1823"
FT                   /id="PRO_0000014110"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  31935 MW;  7F0BCD47FD2553A1 CRC64;
     MAESDRLLGG YDPNAGYSAH AGAQPQRIPV PSLLRALLSE HLDAGYAAVA AERERAAAPR
     CWQARAVSWM WQALAATLVA AVFAAAVAQA RSVAPGVRAA QQLLVASVRS TQAAATTLAQ
     RRSTLSAKVD DVRRIVLADD AEGQRLLARL DVLSLAAASA PVVGPGLTVT VTDPGASPNL
     SDVSKQRVSG SQQIILDRDL QLVVNSLWES GAEAISIDGV RIGPNVTIRQ AGGAILVDNN
     PTSSPYTILA VGPPHAMQDV FDRSAGLYRL RLLETSYGVG VSVNVGDGLA LPAGATRDVK
     FAKQIGP