ID   Y1825_MYCTU             Reviewed;         292 AA.
AC   P9WFG3; L0T9D2; P64895; Q50608;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=UPF0749 protein Rv1825;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv1825; ORFNames=MTCY1A11.18c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0749 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44591.1; -; Genomic_DNA.
DR   PIR; B70721; B70721.
DR   RefSeq; NP_216341.1; NC_000962.3.
DR   RefSeq; WP_003899038.1; NZ_NVQJ01000013.1.
DR   PDB; 3GMG; X-ray; 1.50 A; A/B=133-292.
DR   PDBsum; 3GMG; -.
DR   AlphaFoldDB; P9WFG3; -.
DR   SMR; P9WFG3; -.
DR   STRING; 83332.Rv1825; -.
DR   PaxDb; P9WFG3; -.
DR   DNASU; 885726; -.
DR   GeneID; 45425799; -.
DR   GeneID; 885726; -.
DR   KEGG; mtu:Rv1825; -.
DR   TubercuList; Rv1825; -.
DR   eggNOG; COG3879; Bacteria.
DR   OMA; GLWPPRV; -.
DR   PhylomeDB; P9WFG3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR010273; DUF881.
DR   PANTHER; PTHR37313; PTHR37313; 1.
DR   Pfam; PF05949; DUF881; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..292
FT                   /note="UPF0749 protein Rv1825"
FT                   /id="PRO_0000014112"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           150..157
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          163..173
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   HELIX           181..193
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          197..202
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          207..209
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          216..219
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          222..225
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          228..230
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          232..240
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   HELIX           242..249
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   HELIX           255..261
FT                   /evidence="ECO:0007829|PDB:3GMG"
FT   STRAND          265..276
FT                   /evidence="ECO:0007829|PDB:3GMG"
SQ   SEQUENCE   292 AA;  30645 MW;  22B2DCED7ADCFCC7 CRC64;
     MSENRPEPVA AETSAATTAR HSQADAGAHD AVRRGRHELP ADHPRSKVGP LRRTRLTEIL
     RGGRSRLVFG TLAILLCLVL GVAIVTQVRQ TDSGDSLETA RPADLLVLLD SLRQREATLN
     AEVIDLQNTL NALQASGNTD QAALESAQAR LAALSILVGA VGATGPGVMI TIDDPGPGVA
     PEVMIDVINE LRAAGAEAIQ INDAHRSVRV GVDTWVVGVP GSLTVDTKVL SPPYSILAIG
     DPPTLAAAMN IPGGAQDGVK RVGGRMVVQQ ADRVDVTALR QPKQHQYAQP VK