ID   Y1828_MYCTO             Reviewed;         247 AA.
AC   P9WME6; L0TAQ6; P67669; Q50605;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT1876;
GN   OrderedLocusNames=MT1876;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P9WME7}.
CC   -!- DOMAIN: Contains an N-terminal DNA-binding domain, a linker region and
CC       a C-terminal effector binding domain. Dimerization is mediated via the
CC       C-terminal domain. {ECO:0000250|UniProtKB:P9WME7}.
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DR   EMBL; AE000516; AAK46149.1; -; Genomic_DNA.
DR   PIR; E70721; E70721.
DR   RefSeq; WP_003409239.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WME6; -.
DR   SMR; P9WME6; -.
DR   EnsemblBacteria; AAK46149; AAK46149; MT1876.
DR   GeneID; 45425802; -.
DR   KEGG; mtc:MT1876; -.
DR   PATRIC; fig|83331.31.peg.2020; -.
DR   HOGENOM; CLU_053650_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF00376; MerR; 1.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..247
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT1876"
FT                   /id="PRO_0000427317"
FT   DOMAIN          11..85
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        14..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   247 AA;  26443 MW;  C3BA9AE7E08B3D37 CRC64;
     MSAPDSPALA GMSIGAVLDL LRPDFPDVTI SKIRFLEAEG LVTPRRASSG YRRFTAYDCA
     RLRFILTAQR DHYLPLKVIR AQLDAQPDGE LPPFGSPYVL PRLVPVAGDS AGGVGSDTAS
     VSLTGIRLSR EDLLERSEVA DELLTALLKA GVITTGPGGF FDEHAVVILQ CARALAEYGV
     EPRHLRAFRS AADRQSDLIA QIAGPLVKAG KAGARDRADD LAREVAALAI TLHTSLIKSA
     VRDVLHR