ID   Y182_METEA              Reviewed;         248 AA.
AC   Q49117; C5AP85;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Uncharacterized oxidoreductase MexAM1_META1p0182;
DE            EC=1.-.-.-;
DE   AltName: Full=ORFC;
GN   OrderedLocusNames=MexAM1_META1p0182;
OS   Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB
OS   9133 / AM1) (Methylobacterium extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=272630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1;
RX   PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA   Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA   Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA   Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA   Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA   Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA   Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA   Lidstrom M.E.;
RT   "Methylobacterium genome sequences: a reference blueprint to investigate
RT   microbial metabolism of C1 compounds from natural and industrial sources.";
RL   PLoS ONE 4:E5584-E5584(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 96-248.
RX   PubMed=8868443; DOI=10.1099/13500872-142-3-675;
RA   Smith L.M., Meijer W.G., Dijkhuizen L., Goodwin P.M.;
RT   "A protein having similarity with methylmalonyl-CoA mutase is required for
RT   the assimilation of methanol and ethanol by Methylobacterium extorquens
RT   AM1.";
RL   Microbiology 142:675-684(1996).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; CP001510; ACS38144.1; -; Genomic_DNA.
DR   EMBL; U28335; AAC44089.1; -; Genomic_DNA.
DR   RefSeq; WP_003597283.1; NC_012808.1.
DR   AlphaFoldDB; Q49117; -.
DR   SMR; Q49117; -.
DR   STRING; 272630.MexAM1_META1p0182; -.
DR   EnsemblBacteria; ACS38144; ACS38144; MexAM1_META1p0182.
DR   KEGG; mea:Mex_1p0182; -.
DR   eggNOG; COG1028; Bacteria.
DR   HOGENOM; CLU_010194_1_3_5; -.
DR   OMA; GALPHMY; -.
DR   OrthoDB; 1821409at2; -.
DR   Proteomes; UP000009081; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..248
FT                   /note="Uncharacterized oxidoreductase MexAM1_META1p0182"
FT                   /id="PRO_0000054884"
FT   ACT_SITE        154
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         141
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   248 AA;  24981 MW;  BFE2E1AEFF2FF96E CRC64;
     MSKLEGKVAV VTGASKGIGA AIAKALAKDG AAVVVNYASS KAGADAVVEA ITAAGGKAIA
     VQADVSQAVQ ARGLVEAAVQ QFGRLDVLVN NSGVYEFAAI EEVTEEHYRR IFDVNVLGVL
     LATQAASKHL GEGGSIINIS SVVTDVLMPT SAVYSGTKGA LNAISGVLAN ELAPRKIRVN
     VVSPGYVVTE GTHTAGIAGS EMEAGLVAQT PLGRSGQPDD IAGVVAFLAS DDARWVTGEV
     INASGGVR