ID   Y1835_MYCTO             Reviewed;         628 AA.
AC   P9WIQ8; L0T9E2; P0A5F5; Q50598;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Putative serine esterase MT1883;
DE            EC=3.1.1.-;
GN   OrderedLocusNames=MT1883;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the CocE/NonD hydrolase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AE000516; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE000516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; D70722; D70722.
DR   AlphaFoldDB; P9WIQ8; -.
DR   SMR; P9WIQ8; -.
DR   ESTHER; myctu-y1835; Cocaine_esterase.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005674; CocE/Ser_esterase.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000383; Xaa-Pro-like_dom.
DR   InterPro; IPR013736; Xaa-Pro_dipept_C.
DR   Pfam; PF02129; Peptidase_S15; 1.
DR   Pfam; PF08530; PepX_C; 1.
DR   SMART; SM00939; PepX_C; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR00976; NonD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Serine esterase.
FT   CHAIN           1..628
FT                   /note="Putative serine esterase MT1883"
FT                   /id="PRO_0000427962"
FT   ACT_SITE        156
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        322
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        350
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   628 AA;  69932 MW;  C03FCA57776DEDCF CRC64;
     MTRRGGSDAA WYSAPDQRSA YPRYRGMRYS SCYVTMRDGV RIAIDLYLPA GLTSAARLPA
     ILHQTRYYRS LQLRWPLRML LGGKPLQHIA ADKRRRRRFV ASGYAWVDVD VRGSGASFGA
     RVCEWSSDEI RDGAEIVDWI VRQPWCNGTV AALGNSYDGT SAELLLVNQH PAVRVIAPCF
     SLFDVYTDIA FPGGIHAAWF TDTWGRYNEA LDRNALHEVV GWWAKLPVTG MQPVQEDRDR
     SLRDGAIAAH RGNYDVHQIA GSLTFRDDVS ASDPYRGQPD ARLEPIGTPI ESGSINLISP
     HNYWRDVQAS GAAIYSYSGW FDGGYAHAAI KRFLTVSTPG SHLILGPWNH TGGWRVDPLR
     GLSRPDFDHD GELLRFIDHH VKGADTGIGS EPPVHYFTMV ENRWKSADTW PPPATTQSYY
     LSADRQLRPD APDCDSGADE YVVDQTAGTG ERSRWRSQVG IGGHVCYPDR KAQDAKLLTY
     TSAPLDHPLE VTGHVVVTLF ITSTSSDGTF FVYLEDVDPR GRVAYITEGQ LRAIHRRLSD
     GPPPYRQVVP YRTFASGDAW PLVPGEIARL TFDLLPTSYL FQPGHRIRIA IAGADASHFA
     ILPGCAPTVR VYRSRMHASR IDLPVIQP