ID   Y1835_MYCTU             Reviewed;         628 AA.
AC   P9WIQ9; L0T9E2; P0A5F5; Q50598;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Putative serine esterase Rv1835c;
DE            EC=3.1.1.-;
GN   OrderedLocusNames=Rv1835c; ORFNames=MTCY1A11.08;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the CocE/NonD hydrolase family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44601.1; -; Genomic_DNA.
DR   PIR; D70722; D70722.
DR   RefSeq; NP_216351.1; NC_000962.3.
DR   RefSeq; WP_003409258.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WIQ9; -.
DR   SMR; P9WIQ9; -.
DR   STRING; 83332.Rv1835c; -.
DR   ESTHER; myctu-y1835; Cocaine_esterase.
DR   PaxDb; P9WIQ9; -.
DR   GeneID; 885877; -.
DR   KEGG; mtu:Rv1835c; -.
DR   TubercuList; Rv1835c; -.
DR   eggNOG; COG2936; Bacteria.
DR   OMA; AHNRWKE; -.
DR   PhylomeDB; P9WIQ9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005674; CocE/Ser_esterase.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000383; Xaa-Pro-like_dom.
DR   InterPro; IPR013736; Xaa-Pro_dipept_C.
DR   Pfam; PF02129; Peptidase_S15; 1.
DR   Pfam; PF08530; PepX_C; 1.
DR   SMART; SM00939; PepX_C; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR00976; NonD; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..628
FT                   /note="Putative serine esterase Rv1835c"
FT                   /id="PRO_0000103908"
FT   ACT_SITE        156
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        322
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        350
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   628 AA;  69932 MW;  C03FCA57776DEDCF CRC64;
     MTRRGGSDAA WYSAPDQRSA YPRYRGMRYS SCYVTMRDGV RIAIDLYLPA GLTSAARLPA
     ILHQTRYYRS LQLRWPLRML LGGKPLQHIA ADKRRRRRFV ASGYAWVDVD VRGSGASFGA
     RVCEWSSDEI RDGAEIVDWI VRQPWCNGTV AALGNSYDGT SAELLLVNQH PAVRVIAPCF
     SLFDVYTDIA FPGGIHAAWF TDTWGRYNEA LDRNALHEVV GWWAKLPVTG MQPVQEDRDR
     SLRDGAIAAH RGNYDVHQIA GSLTFRDDVS ASDPYRGQPD ARLEPIGTPI ESGSINLISP
     HNYWRDVQAS GAAIYSYSGW FDGGYAHAAI KRFLTVSTPG SHLILGPWNH TGGWRVDPLR
     GLSRPDFDHD GELLRFIDHH VKGADTGIGS EPPVHYFTMV ENRWKSADTW PPPATTQSYY
     LSADRQLRPD APDCDSGADE YVVDQTAGTG ERSRWRSQVG IGGHVCYPDR KAQDAKLLTY
     TSAPLDHPLE VTGHVVVTLF ITSTSSDGTF FVYLEDVDPR GRVAYITEGQ LRAIHRRLSD
     GPPPYRQVVP YRTFASGDAW PLVPGEIARL TFDLLPTSYL FQPGHRIRIA IAGADASHFA
     ILPGCAPTVR VYRSRMHASR IDLPVIQP