ID   Y1836_MYCTU             Reviewed;         677 AA.
AC   P9WLQ9; L0T7U5; Q50597;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Uncharacterized protein Rv1836c;
GN   OrderedLocusNames=Rv1836c; ORFNames=MTCY1A11.07;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
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DR   EMBL; AL123456; CCP44602.1; -; Genomic_DNA.
DR   PIR; E70722; E70722.
DR   RefSeq; NP_216352.1; NC_000962.3.
DR   RefSeq; WP_003901265.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WLQ9; -.
DR   SMR; P9WLQ9; -.
DR   STRING; 83332.Rv1836c; -.
DR   PaxDb; P9WLQ9; -.
DR   DNASU; 885707; -.
DR   GeneID; 885707; -.
DR   KEGG; mtu:Rv1836c; -.
DR   TubercuList; Rv1836c; -.
DR   eggNOG; COG2304; Bacteria.
DR   OMA; HTDQSLD; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..677
FT                   /note="Uncharacterized protein Rv1836c"
FT                   /id="PRO_0000103910"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   677 AA;  69677 MW;  156DDE8C8C78E0A7 CRC64;
     MGRHSKPDPE DSVDDLSDGH AAEQQHWEDI SGSYDYPGVD QPDDGPLSSE GHYSAVGGYS
     ASGSEDYPDI PPRPDWEPTG AEPIAAAPPP LFRFGHRGPG DWQAGHRSAD GRRGVSIGVI
     VALVAVVVMV AGVILWRFFG DALSNRSHTA AARCVGGKDT VAVIADPSIA DQVKESADSY
     NASAGPVGDR CVAVAVTSAG SDAVINGFIG KWPTELGGQP GLWIPSSSIS AARLTGAAGS
     QAISDSRSLV ISPVLLAVRP ELQQALANQN WAALPGLQTN PNSLSGLDLP AWGSLRLAMP
     SSGNGDAAYL AGEAVAAASA PAGAPATAGI GAVRTLMGAR PKLADDSLTA AMDTLLKPGD
     VATAPVHAVV TTEQQLFQRG QSLSDAENTL GSWLPPGPAA VADYPTVLLS GAWLSQEQTS
     AASAFARYLH KPEQLAKLAR AGFRVSDVKP PSSPVTSFPA LPSTLSVGDD SMRATLADTM
     VTASAGVAAT IMLDQSMPND EGGNSRLSNV VAALENRIKA MPPSSVVGLW TFDGREGRTE
     VPAGPLADPV NGQPRPAALT AALGKQYSSG GGAVSFTTLR LIYQEMLANY RVGQANSVLV
     ITAGPHTDQT LDGPGLQDFI RKSADPAKPI AVNIIDFGAD PDRATWEAVA QLSGGSYQNL
     ETSASPDLAT AVNIFLS