ID   Y183_HAEIN              Reviewed;         481 AA.
AC   P44555;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Uncharacterized transporter HI_0183;
GN   OrderedLocusNames=HI_0183;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21852.1; -; Genomic_DNA.
DR   PIR; I64144; I64144.
DR   RefSeq; NP_438351.1; NC_000907.1.
DR   AlphaFoldDB; P44555; -.
DR   SMR; P44555; -.
DR   STRING; 71421.HI_0183; -.
DR   EnsemblBacteria; AAC21852; AAC21852; HI_0183.
DR   KEGG; hin:HI_0183; -.
DR   PATRIC; fig|71421.8.peg.187; -.
DR   eggNOG; COG1115; Bacteria.
DR   HOGENOM; CLU_024867_0_1_6; -.
DR   OMA; PMMALFY; -.
DR   PhylomeDB; P44555; -.
DR   BioCyc; HINF71421:G1GJ1-193-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015655; F:alanine:sodium symporter activity; IEA:InterPro.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   PANTHER; PTHR30330; PTHR30330; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
DR   TIGRFAMs; TIGR00835; agcS; 1.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..481
FT                   /note="Uncharacterized transporter HI_0183"
FT                   /id="PRO_0000161567"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   481 AA;  52954 MW;  8BA7E44206A7E8EA CRC64;
     MIMEFEFSKM LEEVLTWIVA HLDGPLWDAT IIILLGTGLF FTITTGFVQF RLFPASLREM
     WFGRSVEGSS LTPFQAFTTG LASRVGVGNI GGVATAIALG GEGAVFWMWV TAFIGMSSAF
     AESTLAQLFK IQDKDGSFRG GPAYYIVQGL KSRCMAVAFA LALIFTFGFA FNSVQANSIV
     EATSNAWNWK GEYVGISLVI FTALIIFGGV KRIAIISSNL VPMMALFYLI MAVIILGMHI
     DMIPSVIHRI VQSAFSFDAA AGGMFGALVS KAMMMGIKRG LFSNEAGMGS APNSAAAAHV
     KHPVSQGLVQ MLGVFVDTMI VCTCTAVIIL LSNNYGSETL KSISLTQNAL QYHIGEFGAH
     FLAFILLLFA YSSIIGNYAY AESNIRFIKN KPWLVLLFRL MVLFFVYFGA VRSGNVVWNF
     ADTVMAVMAI INLIAILMLS PIVWKLMKDY QRQLKEGKTP EFKIDEYPEL RKKIFDSRIW
     K