ID   CAPSD_VESVA             Reviewed;         701 AA.
AC   P89681;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 3.
DT   07-OCT-2020, entry version 61.
DE   RecName: Full=Capsid protein;
DE            Short=CP;
DE   AltName: Full=Coat protein;
DE   AltName: Full=VP1;
DE   Flags: Precursor;
GN   ORFNames=ORF2;
OS   Vesicular exanthema of swine virus serotype A48 (isolate Swine/United
OS   States/A48/1948) (VESV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Caliciviridae; Vesivirus.
OX   NCBI_TaxID=85617;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9660070; DOI=10.1016/s0168-1702(98)00013-6;
RA   Neill J.D., Meyer R.F., Seal B.S.;
RT   "The capsid protein of vesicular exanthema of swine virus serotype A48:
RT   relationship to the capsid protein of other animal caliciviruses.";
RL   Virus Res. 54:39-50(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Neill J.D., Seal B.S., Ridpath J.F.;
RT   "Complete nucleotide sequence of the genomic RNA of vesicular exanthema of
RT   swine virus A48.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Capsid protein self-assembles to form an icosahedral capsid
CC       with a T=3 symmetry, about 38 nm in diameter, and consisting of 180
CC       capsid proteins. A smaller form of capsid with a diameter of 23 nm
CC       might be capsid proteins assembled as icosahedron with T=1 symmetry.
CC       The capsid encapsulates the genomic RNA and VP2 proteins. Attaches
CC       virion to target cells. Once attached, the virion is endocytosed.
CC       Acidification of the endosome induces conformational change of capsid
CC       protein thereby injecting virus genomic RNA into host cytoplasm (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Homomultimer. May bind to VP3 and Vpg proteins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC   -!- PTM: Cleaved by virus calcivirin to produce mature capsid protein.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the caliciviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; U76874; AAC13889.2; -; Genomic_RNA.
DR   RefSeq; NP_066256.1; NC_002551.1.
DR   SMR; P89681; -.
DR   GeneID; 911832; -.
DR   KEGG; vg:911832; -.
DR   Proteomes; UP000007661; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039617; C:T=3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   CDD; cd00205; rhv_like; 1.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR004005; Calicivirus_coat.
DR   InterPro; IPR033703; Rhv-like.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF00915; Calici_coat; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host cytoplasm; Reference proteome;
KW   T=3 icosahedral capsid protein; Virion.
FT   PROPEP          1..152
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000402463"
FT   CHAIN           153..701
FT                   /note="Capsid protein"
FT                   /id="PRO_0000402464"
SQ   SEQUENCE   701 AA;  77477 MW;  BE8FCFD9D44DF62A CRC64;
     MATTHTLLSF DNLEFLLHRK DLTDLYGKRC GTLNLVINPY ELFLPDELDD DCCDDPFNCC
     FSDVYASIGT EYSYIDPPDL IYEEHCATNG TWPDGTPCEP ILPPFTITGT HHYYATKPGE
     VVSGILSKLR VFLGSLLRST ADVNSNFTFR AESDGPGSTE IVTEEQGTIV QQQPAPAPTA
     LATLATASTG KSVEQEWMTF FSYHTSINWS TVESQGKVLY SQALNPSINP YLDHISKLYS
     TWSGGIDVRF TVSGSGVFGG KLAALLVPPG VEPIESVSML QYPHVLFDAR QTEPVIFTIP
     DIRKTLFHSM DETDTTKLVI MVYKNGADTK TTCSITVETR PSADFTFALL KPPGSLIKHG
     SIPSDLIPRN SAHWLGNRWW SMISGFSVQP RVFQSNRHFD FDSTTTGWST PYYIPIEITI
     TAKVKGNNHW YHVIAHDKAL VPGIPDGWPD TTIPSEVHAS NGNFDYAKGF HDDKEIVNPA
     NNNTHFKGTY ICGTLSTIKD PEKAENQSES QKKSSTMYVA TADLGDNKVK PQHKISSQKL
     VVYFDGPEKD LTMNATLSPL GYTLVDDQPI GSNSSTVVRI ATLPEAFTQG GNYPIFYVNK
     TNKGYFDKAT TDCYNSQILM TSQRLAEGNY SLPPDSLAVY RITDSSSQWF DIGINHDGFS
     YVGLPDLPAD LTFPLTSTFM GVQLARVKLA SKVKVTRNSI K