ID   Y1841_MYCTO             Reviewed;         345 AA.
AC   P9WLQ6; L0T7V1; Q50593;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Uncharacterized protein MT1889;
GN   OrderedLocusNames=MT1889;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TerC family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46160.1; -; Genomic_DNA.
DR   PIR; A70664; A70664.
DR   RefSeq; WP_003917538.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLQ6; -.
DR   SMR; P9WLQ6; -.
DR   EnsemblBacteria; AAK46160; AAK46160; MT1889.
DR   KEGG; mtc:MT1889; -.
DR   PATRIC; fig|83331.31.peg.2033; -.
DR   HOGENOM; CLU_015237_4_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..345
FT                   /note="Uncharacterized protein MT1889"
FT                   /id="PRO_0000427437"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..198
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          217..280
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          285..342
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   345 AA;  36637 MW;  9C2DD3572117C401 CRC64;
     MDVLSAVLLA LLLIGANAFF VGAEFALISA RRDRLEALAE QGKATAVTVI RAGEQLPAML
     TGAQLGVTVS SILLGRVGEP AVVKLLQLSF GLSGVPPALL HTLSLAIVVA LHVLLGEMVP
     KNIALAGPER TAMLLVPPYL VYVRLARPFI AVYNNCANAI LRLVGVQPKD ELDIAVSTAE
     LSEMIAESLS EGLLDHEEHT RLTRALRIRT RLVADVAVPL VNIRAVQVSA VGSGPTIGGV
     EQALAQTGYS RFPVVDRGGR FIGYLHIKDV LTLGDNPQTV IDLAVVRPLP RVPQSLPLAD
     ALSRMRRINS HLALVTADNG SVVGMVALED VVEDLVGTMR DGTHR