ID   Y1841_MYCTU             Reviewed;         345 AA.
AC   P9WLQ7; L0T7V1; Q50593;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Uncharacterized protein Rv1841c;
GN   OrderedLocusNames=Rv1841c; ORFNames=MTCY1A11.03, MTCY359.32;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TerC family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44607.1; -; Genomic_DNA.
DR   PIR; A70664; A70664.
DR   RefSeq; NP_216357.1; NC_000962.3.
DR   RefSeq; WP_003900419.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WLQ7; -.
DR   SMR; P9WLQ7; -.
DR   STRING; 83332.Rv1841c; -.
DR   PaxDb; P9WLQ7; -.
DR   GeneID; 885656; -.
DR   KEGG; mtu:Rv1841c; -.
DR   TubercuList; Rv1841c; -.
DR   eggNOG; COG1253; Bacteria.
DR   OMA; YLTMEDV; -.
DR   PhylomeDB; P9WLQ7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..345
FT                   /note="Uncharacterized protein Rv1841c"
FT                   /id="PRO_0000103913"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..198
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          217..280
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          285..342
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   345 AA;  36685 MW;  8872985865488F01 CRC64;
     MDVLSAVLLA LLLIGANAFF VGAEFALISA RRDRLEALAE QGKATAVTVI RAGEQLPAML
     TGAQLGVTVS SILLGRVGEP AVVKLLQLSF GLSGVPPALL HTLSLAIVVA LHVLLGEMVP
     KNIALAGPER TAMLLVPPYL VYVRLARPFI AFYNNCANAI LRLVGVQPKD ELDIAVSTAE
     LSEMIAESLS EGLLDHEEHT RLTRALRIRT RLVADVAVPL VNIRAVQVSA VGSGPTIGGV
     EQALAQTGYS RFPVVDRGGR FIGYLHIKDV LTLGDNPQTV IDLAVVRPLP RVPQSLPLAD
     ALSRMRRINS HLALVTADNG SVVGMVALED VVEDLVGTMR DGTHR